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Literature summary extracted from

  • Lupidi, G.; Bollettini, M.; Venardi, G.; Marmocchi, F.; Rotilio, G.
    Functional residues on the enzyme active site of glyoxalase I from bovine brain (2001), Prep. Biochem. Biotechnol., 31, 317-329.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.5 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide 10 mM, 65% inhibition Bos taurus
4.4.1.5 2,3-Butanedione time and concentration dependent inactivation Bos taurus
4.4.1.5 2,4,6-trinnitrobenzenesulphonic acid 2 mM, 60% inhibition Bos taurus
4.4.1.5 diethyldicarbonate 2 mM, complete inhibition Bos taurus
4.4.1.5 N-bromsuccinimide 0.0032 mM, 35% inhibition Bos taurus
4.4.1.5 p-hydroxymercuribenzene sulfonate 1 mM, 64% inhibition Bos taurus
4.4.1.5 Phenylglyoxal
-
 Bos taurus
4.4.1.5 S-hexylglutathione competitive inhibition Bos taurus
4.4.1.5 Tetranitromethane 2 mM, 30% inhibition Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.5 glutathione-methylglyoxal hemithioacetal Homo sapiens glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione (R)-S-lactoylglutathione
-
 ?
4.4.1.5 glutathione-methylglyoxal hemithioacetal Saccharomyces cerevisiae glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione (R)-S-lactoylglutathione
-
 ?
4.4.1.5 glutathione-methylglyoxal hemithioacetal Bos taurus glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione (R)-S-lactoylglutathione
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Bos taurus
-
-
-
4.4.1.5 Homo sapiens
-
-
-
4.4.1.5 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.4.1.5
-
 Homo sapiens
4.4.1.5
-
 Saccharomyces cerevisiae
4.4.1.5
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.5 glutathione-methylglyoxal hemithioacetal glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione Homo sapiens (R)-S-lactoylglutathione
-
 ?
4.4.1.5 glutathione-methylglyoxal hemithioacetal glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione Saccharomyces cerevisiae (R)-S-lactoylglutathione
-
 ?
4.4.1.5 glutathione-methylglyoxal hemithioacetal glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione Bos taurus (R)-S-lactoylglutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.5 glyoxalase I
-
 Homo sapiens
4.4.1.5 glyoxalase I
-
 Saccharomyces cerevisiae
4.4.1.5 glyoxalase I
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.4.1.5 0.4
-
 Phenylglyoxal
-
 Bos taurus
4.4.1.5 4.1
-
 2,3-Butanedione
-
 Bos taurus