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Literature summary extracted from

  • Baunaure, F.; Eldin, P.; Cathiard, A.M.; Vial, H.
    Characterization of a non-mitochondrial type I phosphatidylserine decarboxylase in Plasmodium falciparum (2004), Mol. Microbiol., 51, 33-46.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.65 Triton X-100 enzyme activity depends on presence of Triton X-100, optimum concentration 0.052% Plasmodium falciparum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.65
-
 Plasmodium falciparum

Protein Variants

EC Number Protein Variants Comment Organism
4.1.1.65 G315A no processing of pro-enzyme, pro-enzyme is inactive Plasmodium falciparum
4.1.1.65 G315A/S316A no processing of pro-enzyme, pro-enzyme is inactive Plasmodium falciparum
4.1.1.65 S316A no processing of pro-enzyme Plasmodium falciparum
4.1.1.65 S316T no processing of pro-enzyme Plasmodium falciparum
4.1.1.65 V314L/S317T processing occurs to a slightly greater extent as in wild type, enzyme is twice as active Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.65 63
-
 phosphatidyl-L-serine pH 6.8, recombinant enzyme Plasmodium falciparum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.65 membrane
-
 Plasmodium falciparum 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.65 35000
-
 x * 42600, deduced from gene sequence, x * 35000, SDS-PAGE Plasmodium falciparum
4.1.1.65 42600
-
 x * 42600, deduced from gene sequence, x * 35000, SDS-PAGE Plasmodium falciparum

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.65 Plasmodium falciparum Q9GPP8 parasite-encoded enzyme in human erythrocytes
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.65 Phosphatidyl-L-serine
-
 Plasmodium falciparum Phosphatidylethanolamine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.65 ? x * 42600, deduced from gene sequence, x * 35000, SDS-PAGE Plasmodium falciparum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.65 6.8
-
 strictly pH-dependent Plasmodium falciparum