Literature summary extracted from

Abato, P.; Yuen, C.M.; Cubanski, J.Y.; Seto, C.T.
Inhibitors of plasmin that extend into both the S and S' binding sites: cooperative interactions between S1 and S2 (2002), J. Org. Chem., 67, 1184-1191.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.7	2-(3-[3-[(6-amino-hexyl)-(2-benzyloxycarbonylamino-3-phenyl-propionyl)-amino]-2-oxo-cyclohexyl]-propionylamino)-3-(1H-indol-3-yl)-propionic acid methyl ester	IC50: 0.024 mM	Homo sapiens
3.4.21.7	2-[3-(3-[(6-amino-hexyl)-[2-benzyloxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-amino]-2-oxo-cyclohexyl)-propionylamino]-3-(1H-indol-3-yl)-propionic acid methyl ester	IC50: 0.02 mM	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.7	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.7	D-Val-Leu-Lys-4-nitroanilide + H2O	-	Homo sapiens	D-Val-Leu-Lys + 4-nitroaniline	-	?

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
3.4.21.7	0.02	-	IC50: 0.02 mM	Homo sapiens	2-[3-(3-[(6-amino-hexyl)-[2-benzyloxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-amino]-2-oxo-cyclohexyl)-propionylamino]-3-(1H-indol-3-yl)-propionic acid methyl ester
3.4.21.7	0.024	-	IC50: 0.024 mM	Homo sapiens	2-(3-[3-[(6-amino-hexyl)-(2-benzyloxycarbonylamino-3-phenyl-propionyl)-amino]-2-oxo-cyclohexyl]-propionylamino)-3-(1H-indol-3-yl)-propionic acid methyl ester

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Release 2023.1 (January 2023)