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Literature summary extracted from

  • Kang, Y.; Viswanath, V.; Jha, N.; Qiao, X.; Mo, J.Q.; Andersen, J.K.
    Brain gamma-glutamyl cysteine synthetase (GCS) mRNA expression patterns correlate with regional-specific enzyme activities and glutathione levels (1999), J. Neurosci. Res., 58, 436-441.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.2 ATP + L-Glu + L-Cys Mus musculus first and rate-limiting step in glutathione biosynthesis ADP + phosphate + gamma-L-Glu-L-Cys
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.2 brain
-
 Mus musculus
-
6.3.2.2 brain cortex
-
 Mus musculus
-
6.3.2.2 cerebellum
-
 Mus musculus
-
6.3.2.2 hippocampus
-
 Mus musculus
-
6.3.2.2 additional information correlating regional-specific expression and activity pattern, levels of heavy and light subunit are similar, distribution in brain Mus musculus
-
6.3.2.2 neostriatum lower levels Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.2 ATP + L-Glu + L-2-aminobutyrate
-
 Mus musculus ADP + phosphate + L-Glu-2-aminobutyrate
-
 ?
6.3.2.2 ATP + L-Glu + L-Cys
-
 Mus musculus ADP + phosphate + gamma-L-Glu-L-Cys
-
 ?
6.3.2.2 ATP + L-Glu + L-Cys first and rate-limiting step in glutathione biosynthesis Mus musculus ADP + phosphate + gamma-L-Glu-L-Cys
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.2.2 More the dimeric enzyme is composed of a heavy, catalytic subunit and a light, regulatory subunit Mus musculus

Synonyms

EC Number Synonyms Comment Organism
6.3.2.2 gamma-Glutamylcysteine synthetase
-
 Mus musculus
6.3.2.2 GCS
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.3.2.2 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.2.2 8
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.2 ATP
-
 Mus musculus