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Literature summary extracted from

  • Combrink, K.D.; Guelgeze, H.B.; Meanwell, N.A.; Pearce, B.C.; Zulan, P.; Bisacchi, G.S.; Roberts, D.G.; Stanley, P.; Seiler, S.M.
    1,2-Benzisothiazol-3-one 1,1-dioxide inhibitors of human mast cell tryptase (1998), J. Med. Chem., 41, 4854-4860.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.59 medicine potent and selective inhibitor of tryptase will be an essential tool to determine the role of tryptase in inflammation and other processes, tryptase plays a role in asthma and other allergic and inflammatory skin diseases like psoriasis and atopic dermatitis Homo sapiens

General Stability

EC Number General Stability Organism
3.4.21.59 stabilized by heparin proteoglycans Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.59 1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl-methyl 4-[[(phenylmethoxy)carbonyl]amino]-benzoate
-
 Homo sapiens
3.4.21.59 1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl-methyl 5-[[(phenylmethoxy)carbonyl]amino]-pentanoate
-
 Homo sapiens
3.4.21.59 1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl-methyl N-[(phenylmethoxy)carbonyl]-beta-alanate
-
 Homo sapiens
3.4.21.59 1,2-benzisothiazol-3-one 1,1-dioxide
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.59 secretory granule
-
 Homo sapiens 30141
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.59 Homo sapiens
-
 human
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Synonyms

EC Number Synonyms Comment Organism
3.4.21.59 human mast cell tryptase
-
 Homo sapiens