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Literature summary extracted from

  • Tsimihodimos, V.; Karabina, S.A.; Tambaki, A.P.; Bairaktari, E.; Miltiadous, G.; Goudevenos, J.A.; Cariolou, M.A.; Chapman, M.J.; Tselepis, A.D.; Elisaf, M.
    Altered distribution of platelet-activating factor-acetylhydrolase activity between LDL and HDL as a function of the severity of hypercholesterolemia (2002), J. Lipid Res., 43, 256-263.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.47 additional information the enzyme is associated with low-density lipoprotein LDL and high-density lipoprotein HDL particles Homo sapiens

Application

EC Number Application Comment Organism
3.1.1.47 diagnostics the ratio of the HDL-associated enzyme to total plasma enzyme activity is a useful marker for atherogenicity in subjects with primary hypercholesterolemia Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O Homo sapiens i.e. platelet-activation factor 1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 additional information Homo sapiens individuals with primary heterozygous or homozygous familial hypercholesterolemia show enhanced plasma enzyme activity compared to normolipidemic controls, thereby the level of plasma LDL, to which the enzyme is associated, is increased as well as the enzyme activity per LDL particle, level and activity of HDL-associated enzyme is unaltered ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.47 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor Homo sapiens 1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 additional information lipoprotein-associated phospholipase A2 activity Homo sapiens ?
-
 ?
3.1.1.47 additional information individuals with primary heterozygous or homozygous familial hypercholesterolemia show enhanced plasma enzyme activity compared to normolipidemic controls, thereby the level of plasma LDL, to which the enzyme is associated, is increased as well as the enzyme activity per LDL particle, level and activity of HDL-associated enzyme is unaltered Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.47 lipoprotein-associated phospholipase A2
-
 Homo sapiens
3.1.1.47 PAF-AH
-
 Homo sapiens
3.1.1.47 platelet-activating factor-acetylhydrolase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.47 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.47 7.4
-
 assay at Homo sapiens