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Literature summary extracted from

  • Howard, O.M.; Dong, H.F.; Yang, D.; Raben, N.; Nagaraju, K.; Rosen, A.; Casciola-Rosen, L.; Hartlein, M.; Kron, M.; Yiadom, K.; Dwivedi, S.; Plotz, P.H.; Oppenheim, J.J.
    Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells (2002), J. Exp. Med., 196, 781-791.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.21 ATP + L-histidine + tRNAHis Homo sapiens
-
 AMP + diphosphate + L-histidyl-tRNAHis
-
 ?
6.1.1.21 additional information Homo sapiens determination of enzyme-induced chemotactic activity of human cells, e.g. leukocytes and primary neutrophils, to the enzyme ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.21 Homo sapiens
-
 His-tagged recombinant deletion mutant lacking the N-terminal 60 amino acid resdiues and His-tagged recombinant N-terminal part comprising residues 1-48
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.21 ATP + L-histidine + tRNAHis
-
 Homo sapiens AMP + diphosphate + L-histidyl-tRNAHis
-
 ?
6.1.1.21 additional information determination of enzyme-induced chemotactic activity of human cells, e.g. leukocytes and primary neutrophils, to the enzyme Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.21 HisRS
-
 Homo sapiens
6.1.1.21 Histidine translase
-
 Homo sapiens
6.1.1.21 histidine-tRNA ligase
-
 Homo sapiens
6.1.1.21 histidine-tRNA ligase homolog
-
 Homo sapiens
6.1.1.21 Histidyl-transfer ribonucleate synthetase
-
 Homo sapiens
6.1.1.21 Histidyl-tRNA synthetase
-
 Homo sapiens
6.1.1.21 Jo-1
-
 Homo sapiens
6.1.1.21 Jo-1 antigen
-
 Homo sapiens
6.1.1.21 Synthetase, histidyl-transfer ribonucleate
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.21 ATP
-
 Homo sapiens