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Literature summary extracted from

  • Gullner, G.; Komives, T.; Rennenberg, H.
    Enhanced tolerance of transgenic poplar plants overexpressing gamma-glutamylcysteine synthetase towards chloroacetanilide herbicides (2001), J. Exp. Bot., 52, 971-979.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.2.2 2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)-acetamide i.e. metolachlor, a herbicide that decreases the plant growth and and biomass, induction of enzyme expression, enhanced enzyme activity leads to enhanced detoxification activity Populus tremula x Populus alba
6.3.2.2 2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methylphenyl)-acetamide i.e. acetochlor, a herbicide that decreases the plant growth and and biomass, induction of enzyme expression, enhanced enzyme activity leads to enhanced detoxification activity Populus tremula x Populus alba

Protein Variants

EC Number Protein Variants Comment Organism
6.3.2.2 additional information construction of transgenic poplar plants expressing the bacterial enzyme in the cytosol and chloroplasts, transgenic plants show increased enzyme expression and induction, as well as increased detoxification activity and less phytootxic effects by the herbcides, overview Populus tremula x Populus alba

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.2 ATP + L-Glu + L-Cys Populus tremula x Populus alba the enzyme is involved in the biosynthesis of GSH, which is used for detoxification of herbicides by the plant ADP + phosphate + gamma-L-Glu-L-Cys
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.2 Populus tremula x Populus alba
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 hybrid, INRA-clone Nr. 717-1-B4
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.2 leaf
-
 Populus tremula x Populus alba
-
6.3.2.2 root
-
 Populus tremula x Populus alba
-
6.3.2.2 shoot
-
 Populus tremula x Populus alba
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.2 ATP + L-Glu + L-Cys
-
 Populus tremula x Populus alba ADP + phosphate + gamma-L-Glu-L-Cys
-
 ?
6.3.2.2 ATP + L-Glu + L-Cys the enzyme is involved in the biosynthesis of GSH, which is used for detoxification of herbicides by the plant Populus tremula x Populus alba ADP + phosphate + gamma-L-Glu-L-Cys
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.2 gamma-Glutamylcysteine synthetase
-
 Populus tremula x Populus alba

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.2 ATP
-
 Populus tremula x Populus alba