Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Briganti, F.; Tilli, S.; Mincione, G.; Mincione, F.; Menabuoni, L.; Supuran, C.T.
    Carbonic anhydrase inhibitors. Metal complexes of 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide with topical intraocular pressure lowering properties: The influence of metal ions upon the pharmacological activity (2000), J. Enzyme Inhib., 15, 185-200.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.1 CA I and CA II cDNA expressed in Escherichia coli BL21 (DE3) Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
 Bos taurus
4.2.1.1 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
4.2.1.1 acetazolamide
-
 Bos taurus
4.2.1.1 acetazolamide
-
 Homo sapiens
4.2.1.1 benzolamide
-
 Bos taurus
4.2.1.1 benzolamide
-
 Homo sapiens
4.2.1.1 chlorazolamide
-
 Bos taurus
4.2.1.1 chlorazolamide
-
 Homo sapiens
4.2.1.1 dorzolamide
-
 Bos taurus
4.2.1.1 dorzolamide
-
 Homo sapiens
4.2.1.1 ethoxzolamide
-
 Bos taurus
4.2.1.1 ethoxzolamide
-
 Homo sapiens
4.2.1.1 methazolamide
-
 Bos taurus
4.2.1.1 methazolamide
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.1 microsome
-
 Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.1 Zn2+
-
 Homo sapiens
4.2.1.1 Zn2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.1 H2CO3 Homo sapiens
-
 CO2 + H2O
-
 r
4.2.1.1 H2CO3 Bos taurus
-
 CO2 + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Bos taurus
-
-
-
4.2.1.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.1
-
 Homo sapiens
4.2.1.1
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.1 lung
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 H2CO3
-
 Homo sapiens CO2 + H2O
-
 r
4.2.1.1 H2CO3
-
 Bos taurus CO2 + H2O
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 bCA IV
-
 Homo sapiens
4.2.1.1 bCA IV
-
 Bos taurus
4.2.1.1 CA
-
 Homo sapiens
4.2.1.1 CA
-
 Bos taurus
4.2.1.1 CA I
-
 Homo sapiens
4.2.1.1 CA II
-
 Homo sapiens
4.2.1.1 CA IV
-
 Homo sapiens
4.2.1.1 carbonic anhydrase
-
 Homo sapiens
4.2.1.1 carbonic anhydrase
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.1 0.000003
-
 chlorazolamide pH 7.4, 25°C, hCA II Homo sapiens
4.2.1.1 0.000008
-
 ethoxzolamide pH 7.4, 25°C, hCA II Homo sapiens
4.2.1.1 0.000009
-
 dorzolamide pH 7.4, 25°C, hCA II Homo sapiens
4.2.1.1 0.000009
-
 benzolamide pH 7.4, 25°C, hCA II Homo sapiens
4.2.1.1 0.000012
-
 benzolamide pH 7.4, 25°C, bCA IV Bos taurus
4.2.1.1 0.000012
-
 acetazolamide pH 7.4, 25°C, hCA II Homo sapiens
4.2.1.1 0.000013
-
 ethoxzolamide pH 7.4, 25°C, bCA IV Bos taurus
4.2.1.1 0.000014
-
 methazolamide pH 7.4, 25°C, hCA II Homo sapiens
4.2.1.1 0.000015
-
 chlorazolamide pH 7.4, 25°C, bCA IV Bos taurus
4.2.1.1 0.000015
-
 chlorazolamide pH 7.4, 25°C, hCA I Homo sapiens
4.2.1.1 0.000018
-
 benzolamide pH 7.4, 25°C, hCA I Homo sapiens
4.2.1.1 0.000025
-
 ethoxzolamide pH 7.4, 25°C, hCA I Homo sapiens
4.2.1.1 0.000043
-
 dorzolamide pH 7.4, 25°C, bCA IV Bos taurus
4.2.1.1 0.00022
-
 acetazolamide pH 7.4, 25°C, bCA IV Bos taurus
4.2.1.1 0.00024
-
 methazolamide pH 7.4, 25°C, bCA IV Bos taurus
4.2.1.1 0.00078
-
 methazolamide pH 7.4, 25°C, hCA I Homo sapiens
4.2.1.1 0.0009
-
 acetazolamide pH 7.4, 25°C, hCA I Homo sapiens
4.2.1.1 0.05
-
 dorzolamide pH 7.4, 25°C, hCA I Homo sapiens