BRENDA - Enzyme Database show

Carbonic anhydrase inhibitors. Metal complexes of 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide with topical intraocular pressure lowering properties: The influence of metal ions upon the pharmacological activity

Briganti, F.; Tilli, S.; Mincione, G.; Mincione, F.; Menabuoni, L.; Supuran, C.T.; J. Enzyme Inhib. 15, 185-200 (2000)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
4.2.1.1
CA I and CA II cDNA expressed in Escherichia coli BL21 (DE3)
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.1
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
Bos taurus
4.2.1.1
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
4.2.1.1
acetazolamide
-
Bos taurus
4.2.1.1
acetazolamide
-
Homo sapiens
4.2.1.1
benzolamide
-
Bos taurus
4.2.1.1
benzolamide
-
Homo sapiens
4.2.1.1
chlorazolamide
-
Bos taurus
4.2.1.1
chlorazolamide
-
Homo sapiens
4.2.1.1
dorzolamide
-
Bos taurus
4.2.1.1
dorzolamide
-
Homo sapiens
4.2.1.1
ethoxzolamide
-
Bos taurus
4.2.1.1
ethoxzolamide
-
Homo sapiens
4.2.1.1
methazolamide
-
Bos taurus
4.2.1.1
methazolamide
-
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.2.1.1
microsome
-
Bos taurus
-
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
4.2.1.1
Zn2+
-
Bos taurus
4.2.1.1
Zn2+
-
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.2.1.1
H2CO3
Homo sapiens
-
CO2 + H2O
-
Homo sapiens
r
4.2.1.1
H2CO3
Bos taurus
-
CO2 + H2O
-
Bos taurus
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.1
Bos taurus
-
-
-
4.2.1.1
Homo sapiens
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
4.2.1.1
-
Bos taurus
4.2.1.1
-
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.1
lung
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.1
H2CO3
-
652630
Homo sapiens
CO2 + H2O
-
652630
Homo sapiens
r
4.2.1.1
H2CO3
-
652630
Bos taurus
CO2 + H2O
-
652630
Bos taurus
r
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
4.2.1.1
0.000003
-
chlorazolamide
pH 7.4, 25C, hCA II
Homo sapiens
4.2.1.1
0.000008
-
ethoxzolamide
pH 7.4, 25C, hCA II
Homo sapiens
4.2.1.1
0.000009
-
benzolamide
pH 7.4, 25C, hCA II
Homo sapiens
4.2.1.1
0.000009
-
dorzolamide
pH 7.4, 25C, hCA II
Homo sapiens
4.2.1.1
0.000012
-
acetazolamide
pH 7.4, 25C, hCA II
Homo sapiens
4.2.1.1
0.000012
-
benzolamide
pH 7.4, 25C, bCA IV
Bos taurus
4.2.1.1
0.000013
-
ethoxzolamide
pH 7.4, 25C, bCA IV
Bos taurus
4.2.1.1
0.000014
-
methazolamide
pH 7.4, 25C, hCA II
Homo sapiens
4.2.1.1
0.000015
-
chlorazolamide
pH 7.4, 25C, bCA IV
Bos taurus
4.2.1.1
0.000015
-
chlorazolamide
pH 7.4, 25C, hCA I
Homo sapiens
4.2.1.1
0.000018
-
benzolamide
pH 7.4, 25C, hCA I
Homo sapiens
4.2.1.1
0.000025
-
ethoxzolamide
pH 7.4, 25C, hCA I
Homo sapiens
4.2.1.1
0.000043
-
dorzolamide
pH 7.4, 25C, bCA IV
Bos taurus
4.2.1.1
0.00022
-
acetazolamide
pH 7.4, 25C, bCA IV
Bos taurus
4.2.1.1
0.00024
-
methazolamide
pH 7.4, 25C, bCA IV
Bos taurus
4.2.1.1
0.00078
-
methazolamide
pH 7.4, 25C, hCA I
Homo sapiens
4.2.1.1
0.0009
-
acetazolamide
pH 7.4, 25C, hCA I
Homo sapiens
4.2.1.1
0.05
-
dorzolamide
pH 7.4, 25C, hCA I
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
4.2.1.1
CA I and CA II cDNA expressed in Escherichia coli BL21 (DE3)
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.1
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
Bos taurus
4.2.1.1
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
4.2.1.1
acetazolamide
-
Bos taurus
4.2.1.1
acetazolamide
-
Homo sapiens
4.2.1.1
benzolamide
-
Bos taurus
4.2.1.1
benzolamide
-
Homo sapiens
4.2.1.1
chlorazolamide
-
Bos taurus
4.2.1.1
chlorazolamide
-
Homo sapiens
4.2.1.1
dorzolamide
-
Bos taurus
4.2.1.1
dorzolamide
-
Homo sapiens
4.2.1.1
ethoxzolamide
-
Bos taurus
4.2.1.1
ethoxzolamide
-
Homo sapiens
4.2.1.1
methazolamide
-
Bos taurus
4.2.1.1
methazolamide
-
Homo sapiens
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
4.2.1.1
0.000003
-
chlorazolamide
pH 7.4, 25C, hCA II
Homo sapiens
4.2.1.1
0.000008
-
ethoxzolamide
pH 7.4, 25C, hCA II
Homo sapiens
4.2.1.1
0.000009
-
benzolamide
pH 7.4, 25C, hCA II
Homo sapiens
4.2.1.1
0.000009
-
dorzolamide
pH 7.4, 25C, hCA II
Homo sapiens
4.2.1.1
0.000012
-
acetazolamide
pH 7.4, 25C, hCA II
Homo sapiens
4.2.1.1
0.000012
-
benzolamide
pH 7.4, 25C, bCA IV
Bos taurus
4.2.1.1
0.000013
-
ethoxzolamide
pH 7.4, 25C, bCA IV
Bos taurus
4.2.1.1
0.000014
-
methazolamide
pH 7.4, 25C, hCA II
Homo sapiens
4.2.1.1
0.000015
-
chlorazolamide
pH 7.4, 25C, bCA IV
Bos taurus
4.2.1.1
0.000015
-
chlorazolamide
pH 7.4, 25C, hCA I
Homo sapiens
4.2.1.1
0.000018
-
benzolamide
pH 7.4, 25C, hCA I
Homo sapiens
4.2.1.1
0.000025
-
ethoxzolamide
pH 7.4, 25C, hCA I
Homo sapiens
4.2.1.1
0.000043
-
dorzolamide
pH 7.4, 25C, bCA IV
Bos taurus
4.2.1.1
0.00022
-
acetazolamide
pH 7.4, 25C, bCA IV
Bos taurus
4.2.1.1
0.00024
-
methazolamide
pH 7.4, 25C, bCA IV
Bos taurus
4.2.1.1
0.00078
-
methazolamide
pH 7.4, 25C, hCA I
Homo sapiens
4.2.1.1
0.0009
-
acetazolamide
pH 7.4, 25C, hCA I
Homo sapiens
4.2.1.1
0.05
-
dorzolamide
pH 7.4, 25C, hCA I
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.2.1.1
microsome
-
Bos taurus
-
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
4.2.1.1
Zn2+
-
Bos taurus
4.2.1.1
Zn2+
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.2.1.1
H2CO3
Homo sapiens
-
CO2 + H2O
-
Homo sapiens
r
4.2.1.1
H2CO3
Bos taurus
-
CO2 + H2O
-
Bos taurus
r
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
4.2.1.1
-
Bos taurus
4.2.1.1
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.1
lung
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.1
H2CO3
-
652630
Homo sapiens
CO2 + H2O
-
652630
Homo sapiens
r
4.2.1.1
H2CO3
-
652630
Bos taurus
CO2 + H2O
-
652630
Bos taurus
r