Literature summary extracted from

Park, H.I.; Jin, Y.; Hurst, D.R.; Monroe, C.C.; Lee, S.; Schwartz, M.A.; Sang, Q.X.
The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling (2003), J. Biol. Chem., 278, 51646-51653.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.24.B7	hydroxamate matrix metalloproteinase inhibitors	-	Homo sapiens
3.4.24.B7	MAG-181	mercaptosulfide matrix metalloproteinase inhibitor	Homo sapiens
3.4.24.B7	MAG-182	mercaptosulfide matrix metalloproteinase inhibitor	Homo sapiens
3.4.24.B7	matrix metalloproteinase inhibitor GM6001	-	Homo sapiens
3.4.24.B7	YHJ-294-1	mercaptosulfide matrix metalloproteinase inhibitor	Homo sapiens
3.4.24.B7	YHJ-294-2	mercaptosulfide matrix metalloproteinase inhibitor	Homo sapiens
3.4.24.B7	YHJ-72	mercaptosulfide matrix metalloproteinase inhibitor	Homo sapiens
3.4.24.B7	YHJ-73	mercaptosulfide matrix metalloproteinase inhibitor	Homo sapiens
3.4.24.B7	YHJ-74	mercaptosulfide matrix metalloproteinase inhibitor	Homo sapiens
3.4.24.B7	YHJ-75	mercaptosulfide matrix metalloproteinase inhibitor	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.24.B7	proteins + H2O	Homo sapiens	-	peptides	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.B7	Homo sapiens	-	-	-

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
3.4.24.B7	proteolytic degradation of proteins	active site structure	Homo sapiens	a

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.B7	proteins + H2O	-	Homo sapiens	peptides	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.B7	endometase	-	Homo sapiens
3.4.24.B7	endometase/matrilysin-2	-	Homo sapiens
3.4.24.B7	M10.029	Merops-ID	Homo sapiens
3.4.24.B7	matrix metalloproteinase-26	-	Homo sapiens
3.4.24.B7	MMP-26	-	Homo sapiens
3.4.24.B7	MMP-26/endometase/matrilysin-2	-	Homo sapiens

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
3.4.24.B7	additional information	-	additional information	-	Homo sapiens
3.4.24.B7	0.0000028	-	YHJ-294-2	pH 7.5, 25°C	Homo sapiens
3.4.24.B7	0.0000086	-	YHJ-75	pH 7.5, 25°C	Homo sapiens
3.4.24.B7	0.000017	-	MAG-182	pH 7.5, 25°C	Homo sapiens
3.4.24.B7	0.000028	-	YHJ-73	pH 7.5, 25°C	Homo sapiens
3.4.24.B7	0.000081	-	MAG-181	pH 7.5, 25°C	Homo sapiens
3.4.24.B7	0.000082	-	YHJ-74	pH 7.5, 25°C	Homo sapiens
3.4.24.B7	0.00016	-	YHJ-72	pH 7.5, 25°C	Homo sapiens
3.4.24.B7	0.00045	-	YHJ-294-1	pH 7.5, 25°C	Homo sapiens

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Release 2023.1 (January 2023)