EC Number | Cloned (Comment) | Organism |
---|---|---|
5.3.99.3 | expression of histidine-tagged mPGES-1 in Escherichia coli | Homo sapiens |
EC Number | General Stability | Organism |
---|---|---|
5.3.99.3 | activity in solubilized membranes remains stable for a prolonged time in the presence of reduced glutathione and glycerol | Homo sapiens |
5.3.99.3 | resistant to freeze-thawing | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
5.3.99.3 | 0.16 | - |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate | - |
Homo sapiens | |
5.3.99.3 | 0.16 | - |
prostaglandin G2 | - |
Homo sapiens | |
5.3.99.3 | 0.71 | - |
glutathione | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
5.3.99.3 | microsome | - |
Homo sapiens | - |
- |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
5.3.99.3 | 17500 | - |
x * 17500, SDS-PAGE | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.3.99.3 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
5.3.99.3 | recombinant His-tagged mPGES-1, hydroxyapatite, Ni2+-affinity chromatography | Homo sapiens |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
5.3.99.3 | 0.04 | - |
substrate 15-hydroperoxy-prostaglandin E2 | Homo sapiens |
5.3.99.3 | 0.043 | - |
substrate 5-hydroperoxyeicostetraenoic | Homo sapiens |
5.3.99.3 | 0.17 | - |
substrate cumene hydroperoxide | Homo sapiens |
5.3.99.3 | 0.81 | - |
substrate 1-chloro-2,4-dinitrobenzene | Homo sapiens |
5.3.99.3 | 120 | - |
substrate (5Z,13E)-(15S)-9a,11a-epidioxy-15-hydroxyprosta-5,13-dienoate | Homo sapiens |
5.3.99.3 | 190 | - |
substrate prostaglandin G2 | Homo sapiens |
EC Number | Storage Stability | Organism |
---|---|---|
5.3.99.3 | -20°C, 6 months, no loss of activity | Homo sapiens |
5.3.99.3 | 4°C, solubilized membranes, 10 d, 50% loss of activity | Homo sapiens |
5.3.99.3 | 4°C, solubilized membranes, 24 h, 30% loss of activity | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.3 | (5Z,13E)-(15S)-9a,11a-epidioxy-15-hydroxyprosta-5,13-dienoate + GSH | i.e. prostaglandin H2 | Homo sapiens | (5Z,13E)-(15S)-11a,15-dihydroxyprosta-5,13-dienoate + GSSG | i.e. prostaglandin E2 | ? | |
5.3.99.3 | 1-chloro-2,4-dinitrobenzene + GSH | glutathione S-transferase activity | Homo sapiens | ? | - |
? | |
5.3.99.3 | 15-hydroperoxy-prostaglandin E2 + GSH | - |
Homo sapiens | prostaglandin E2 + GSSG | - |
? | |
5.3.99.3 | 5-hydroperoxyeicosatetraenoic acid + 2 GSH | - |
Homo sapiens | 5-hydroxyeicosatetraenoic acid + GSSG + H2O | - |
? | |
5.3.99.3 | cumene hydroperoxide + 2 GSH | - |
Homo sapiens | cumene hydroxide + GSSG + H2O | - |
? | |
5.3.99.3 | prostaglandin G2 + GSH | - |
Homo sapiens | 15-hydroperoxy-prostaglandine E2 + GSSG | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
5.3.99.3 | ? | x * 17500, SDS-PAGE | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.3.99.3 | mPGES-1 | - |
Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
5.3.99.3 | 21 | - |
glutathione | - |
Homo sapiens | |
5.3.99.3 | 50 | - |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate | - |
Homo sapiens | |
5.3.99.3 | 75 | - |
prostaglandine G2 | - |
Homo sapiens |