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Literature summary extracted from

  • Ko, Y.G.; Kim, E.Y.; Kim, T.; Park, H.; Park, H.S.; Choi, E.J.; Kim, S.
    Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1 (2001), J. Biol. Chem., 276, 6030-6036.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.18 ATP + L-glutamine + tRNAGln Homo sapiens
-
 AMP + diphosphate + L-glutaminyl-tRNAGln
-
 ?
6.1.1.18 additional information Homo sapiens the enzyme interacts with the apoptosis signal-regulating kinase ASK1, which involves the active sites of the enzymes and inhibits AKS1, the association is mediated and enhanced by glutamine, it is inhibited by Fas ligation, the enzyme inhibits ASK1-induced apoptosis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.18 Homo sapiens
-
 purified recombinant His-tagged enzyme expressed in Escherichia coli
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.1.1.18 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.18 ATP + L-glutamine + tRNAGln
-
 Homo sapiens AMP + diphosphate + L-glutaminyl-tRNAGln
-
 ?
6.1.1.18 additional information the enzyme interacts with the apoptosis signal-regulating kinase ASK1, which involves the active sites of the enzymes and inhibits AKS1, the association is mediated and enhanced by glutamine, it is inhibited by Fas ligation, the enzyme inhibits ASK1-induced apoptosis Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.18 Glutaminyl-tRNA synthetase
-
 Homo sapiens
6.1.1.18 QRS
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.18 ATP
-
 Homo sapiens