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Literature summary extracted from

  • Kupke, T.; Hernandez-Acosta, P.; Steinbacher, S.; Culianez-Macia, F.A.
    Arabidopsis thaliana flavoprotein AtHAL3a catalyzes the decarboxylation of 4'-phosphopantothenoylcysteine to 4'-phosphopantetheine, a key step in coenzyme A biosynthesis (2001), J. Biol. Chem., 276, 19190-19196.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.36
-
 Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
4.1.1.36 C158A constructed by sequential polymerase chain reaction Escherichia coli
4.1.1.36 H90N exchange leads to complete inactivation of the enzyme Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.36 (R)-4'-phospho-N-pantothenoylcysteine Escherichia coli
-
 4'-phosphopantetheine + CO2
-
 ?
4.1.1.36 N-[(R)-4'-phosphopantothenoyl]-L-cysteine Arabidopsis thaliana key step in coenzyme A biosynthesis pantotheine 4'-phosphate + CO2
-
 ?
4.1.1.36 N-[(R)-4'-phosphopantothenoyl]-L-cysteine Escherichia coli key step in coenzyme A biosynthestic pathway pantotheine 4'-phosphate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.36 Arabidopsis thaliana Q9SWE5
-
-
4.1.1.36 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.36
-
 Escherichia coli
4.1.1.36
-
 Arabidopsis thaliana

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.36 (R)-4'-phospho-N-pantothenoylcysteine
-
 Escherichia coli 4'-phosphopantetheine + CO2
-
 ?
4.1.1.36 N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 Escherichia coli pantotheine 4'-phosphate + CO2
-
 ?
4.1.1.36 N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 Arabidopsis thaliana pantotheine 4'-phosphate + CO2
-
 ?
4.1.1.36 N-[(R)-4'-phosphopantothenoyl]-L-cysteine key step in coenzyme A biosynthesis Arabidopsis thaliana pantotheine 4'-phosphate + CO2
-
 ?
4.1.1.36 N-[(R)-4'-phosphopantothenoyl]-L-cysteine key step in coenzyme A biosynthestic pathway Escherichia coli pantotheine 4'-phosphate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.36 Dfp
-
 Escherichia coli
4.1.1.36 flavoprotein AtHal3a
-
 Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.36 flavin flavoprotein Escherichia coli