EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.24.B12 | expression in Drosophila S2 cells | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.B12 | TIMP-3 | recombinant human inhibitor protein from Escherichia coli, i.e. tissue inhibitor of metalloproteinases, strong inhibitor with regulatory function | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.B12 | additional information | metalloproteinase | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.B12 | aggrecan + H2O | Homo sapiens | degradation of cartilage matrix | ? | - |
? | |
3.4.24.B12 | proteins + H2O | Homo sapiens | - |
peptides | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.B12 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.B12 | aggrecan + H2O | cleavage site is Glu373-Ala374 | Homo sapiens | ? | - |
? | |
3.4.24.B12 | aggrecan + H2O | degradation of cartilage matrix | Homo sapiens | ? | - |
? | |
3.4.24.B12 | proteins + H2O | - |
Homo sapiens | peptides | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.B12 | ADAM-TS5 | - |
Homo sapiens |
3.4.24.B12 | aggrecanase-2 | - |
Homo sapiens |
3.4.24.B12 | M12.225 | Merops-ID | Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.24.B12 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.24.B12 | 7.5 | - |
assay at | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.24.B12 | 0.00000066 | - |
TIMP-3 | pH 7.5, 37°C | Homo sapiens |