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Literature summary extracted from

  • Sambrano, G.R.; Huang, W.; Faruqi, T.; Mahrus, S.; Craik, C.; Coughlin, S.R.
    Cathepsin G activates protease-activated receptor-4 in human platelets (2000), J. Biol. Chem., 275, 6819-6823.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.20 N-formylmethionyl-leucyl-phenylalanine induces release of enzyme from neutrophils Homo sapiens
3.4.21.20 platelet-activating factor induces release of enzyme from neutrophils Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.20 ecotin
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.20 Ca2+ enzyme triggers calcium mobilization Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.20 additional information Homo sapiens enzyme causes platelet secretion and aggregation mediated by protease-activated receptor-4, i.e. PAR4, triggers calcium mobilization in PAR4-transfected fibroblasts, PAR4-expressing Xenopus oocytes, and washed human platelets, enzyme might mediate platelet-neutrophil interaction at sites of vascular injury or inflammation, regulation of enzyme activity on platelets and protease-activated receptors-1 and -4 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.20 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.20 neutrophil azurophilic granule Homo sapiens
-
3.4.21.20 platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.20 Fibronectin + H2O hydrolysis after methionine, leucine, phenylalanine, lysine, or arginine residues Homo sapiens ?
-
 ?
3.4.21.20 Laminin + H2O hydrolysis after methionine, leucine, phenylalanine, lysine, or arginine residues Homo sapiens ?
-
 ?
3.4.21.20 additional information no activity with PAR1-mutant A2F and PAR4 mutant G1P Homo sapiens ?
-
 ?
3.4.21.20 additional information enzyme causes platelet secretion and aggregation mediated by protease-activated receptor-4, i.e. PAR4, triggers calcium mobilization in PAR4-transfected fibroblasts, PAR4-expressing Xenopus oocytes, and washed human platelets, enzyme might mediate platelet-neutrophil interaction at sites of vascular injury or inflammation, regulation of enzyme activity on platelets and protease-activated receptors-1 and -4 Homo sapiens ?
-
 ?
3.4.21.20 N-succinyl-Ala-Ala-Pro-Phe-thiobenzyl ester + H2O chromogenic substrate Homo sapiens ?
-
 ?
3.4.21.20 protease-activated receptor-1 + H2O i.e. PAR1, activation of platelets by hydrolysis of the receptor protein Homo sapiens ?
-
 ?
3.4.21.20 protease-activated receptor-4 + H2O i.e. PAR4, activation of platelets by hydrolysis of the receptor protein Homo sapiens ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.20 0.000000015
-
 ecotin
-
 Homo sapiens