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Literature summary extracted from

  • McKean, A.L.; Ke, J.; Song, J.; Che, P.; Achenbach, S.; Nikolau, B.J.; Wurtele, E.S.
    Molecular characterization of the non-biotin-containing subunit of 3-methylcrotonyl-CoA carboxylase (2000), J. Biol. Chem., 275, 5582-5590.
    View publication on PubMed

Application

EC Number Application Comment Organism
6.4.1.4 agriculture MCCase is of significance in comprehending how the mevalonate shunt can divert carbon away from the biosynthesis of isoprenoids, such as cholesterol, which has major implications in the prevention of vascular degenerate diseases Arabidopsis thaliana

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.4.1.4 cDNA cloned and expressed in Escherichia coli Arabidopsis sp.

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.4.1.4 60000
-
 x * 85000 + x * 60000, heteromeric enzyme composed of biotin-containing MCC-A and non-biotin-containing MCC-B subunits Arabidopsis thaliana
6.4.1.4 85000
-
 x * 85000 + x * 60000, heteromeric enzyme composed of biotin-containing MCC-A and non-biotin-containing MCC-B subunits Arabidopsis thaliana
6.4.1.4 900000
-
 nondenaturing PAGE, gel filtration Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.4.1.4 ATP + 3-methylcrotonyl-CoA + HCO3- Arabidopsis thaliana pivotal reaction required for both leucine catabolism and isoprenoid metabolism ADP + phosphate + 3-methylglutaconyl-CoA
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.4 Arabidopsis thaliana Q9LDD8 ecotype Columbia
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.4.1.4
-
 Arabidopsis sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.4 ATP + 3-methylcrotonyl-CoA + HCO3-
-
 Arabidopsis thaliana ADP + phosphate + 3-methylglutaconyl-CoA
-
 ir
6.4.1.4 ATP + 3-methylcrotonyl-CoA + HCO3- pivotal reaction required for both leucine catabolism and isoprenoid metabolism Arabidopsis thaliana ADP + phosphate + 3-methylglutaconyl-CoA
-
 ir

Subunits

EC Number Subunits Comment Organism
6.4.1.4 polymer x * 85000 + x * 60000, heteromeric enzyme composed of biotin-containing MCC-A and non-biotin-containing MCC-B subunits Arabidopsis thaliana

Synonyms

EC Number Synonyms Comment Organism
6.4.1.4 3-methylcrotonyl-CoA carboxylase
-
 Arabidopsis thaliana
6.4.1.4 3-methylcrotonyl-CoA:carbon-dioxide ligase (ADP-forming)
-
 Arabidopsis thaliana
6.4.1.4 MCCase
-
 Arabidopsis thaliana