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Literature summary extracted from

  • Howard, L.; Nelson, K.K.; Maciewicz, R.A.; Blobel, C.P.
    Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1 (1999), J. Biol. Chem., 274, 31693-31699.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B9 expression of FLAG-tagged enzyme in COS-7 cells Mus musculus
3.4.24.B9 expression of GST-fusion cytoplasmic enzyme domain in a two-hybrid system in Saccharomyces cerevisiae strain HF7c Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B9 additional information Mus musculus interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme ?
-
 ?
3.4.24.B9 additional information Homo sapiens interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme ?
-
 ?
3.4.24.B9 proteins + H2O Mus musculus
-
 peptides
-
 ?
3.4.24.B9 proteins + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B9 Homo sapiens
-
-
-
3.4.24.B9 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B9 proteolytic modification cleavage of prodomain by furin, interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme Mus musculus
3.4.24.B9 proteolytic modification cleavage of prodomain by furin, interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B9 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B9 additional information interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme Mus musculus ?
-
 ?
3.4.24.B9 additional information interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme Homo sapiens ?
-
 ?
3.4.24.B9 proteins + H2O
-
 Mus musculus peptides
-
 ?
3.4.24.B9 proteins + H2O
-
 Homo sapiens peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B9 M12.209 Merops-ID Mus musculus
3.4.24.B9 M12.209 Merops-ID Homo sapiens
3.4.24.B9 MDC9
-
 Mus musculus
3.4.24.B9 MDC9
-
 Homo sapiens