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Literature summary extracted from

  • Mackey, Z.B.; Niedergang, C.; Murcia, J.M.D.; Leppard, J.; Au, K.; Chen, J.; De Murcia, G.; Tomkinson, A.E.
    DNA ligase III is recruited to DNA strand breaks by a zinc finger motif homologous to that of poly(ADP-ribose) polymerase. Identification of two functionally distinct DNA binding regions within DNA ligase III (1999), J. Biol. Chem., 274, 21679-21687.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.5.1.1 expression in Sf9 insect cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
6.5.1.1 F717L amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant Homo sapiens
6.5.1.1 G712A amino acid substitution within the conserved peptide of DNA ligase IIIbeta, complements Escherichia coli lig mutant Homo sapiens
6.5.1.1 K724E amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant Homo sapiens
6.5.1.1 K727G amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant Homo sapiens
6.5.1.1 K727R amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant Homo sapiens
6.5.1.1 P718A amino acid substitution within the conserved peptide of DNA ligase IIIbeta, complements Escherichia coli lig mutant Homo sapiens
6.5.1.1 P718T amino acid substitution within the conserved peptide of DNA ligase IIIbeta, complements Escherichia coli lig mutant Homo sapiens
6.5.1.1 p719G amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant, thermolabile mutant Homo sapiens
6.5.1.1 R716G amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant Homo sapiens
6.5.1.1 R722Q amino acid substitution within the conserved peptide of DNA ligase IIIbeta, complements Escherichia coli lig mutant Homo sapiens
6.5.1.1 R722V amino acid substitution within the conserved peptide of DNA ligase IIIbeta, complements Escherichia coli lig mutant Homo sapiens
6.5.1.1 R724G amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant Homo sapiens
6.5.1.1 S714I amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens
-
 AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.5.1.1 recombinant DNA ligase III Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 DNA ligase III
-
 Homo sapiens