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Literature summary extracted from

  • Oneda, H.; Inouye, K.
    Interactions of human matrix metalloproteinase 7 (matrilysin) with the inhibitors thiorphan and R-94138 (2001), J. Biochem., 129, 429-435.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.23 medicine development of effective inhibitors useful for cancer therapy Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.23 recombinant pro-matrilysin Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.23 additional information no inhibition with phosphoramidon Homo sapiens
3.4.24.23 R-94138
-
Homo sapiens
3.4.24.23 thiorphan
-
Homo sapiens
3.4.24.23 Zincov
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.23 Homo sapiens
-
human
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.23 (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-L-Ala-L-Arg-NH2 + H2O MOCAc-PLGL(Dpa)AR, Lot 480429 Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.23 matrilysin
-
Homo sapiens
3.4.24.23 Matrix metalloproteinase 7
-
Homo sapiens
3.4.24.23 MMP-7
-
Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.24.23 4 10
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.24.23 0.0105
-
R-94138 pH 7.5, 25°C Homo sapiens
3.4.24.23 0.0112
-
thiorphan pH 7.5, 25°C Homo sapiens
3.4.24.23 0.015
-
thiorphan pH 7.5, 37°C Homo sapiens