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Literature summary extracted from

  • Peters, J.E.; Galloway, D.R.
    Purification and characterization of an active fragment of the LasA protein from Pseudomonas aeruginosa: enhancement of elastase activity (1990), J. Bacteriol., 172, 2236-2240.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B16 cytosol
-
 Pseudomonas aeruginosa 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.B16 22000
-
 x * 22000, SDS-PAGE Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B16 additional information Pseudomonas aeruginosa enzyme activates elastase, and the elastolytic activity of thermolysin, human neutrophil elastase, proteinase K, by interacting with the elastin substrate rather than the other enzyme ?
-
 ?
3.4.24.B16 protein + H2O Pseudomonas aeruginosa
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B16 Pseudomonas aeruginosa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B16 proteolytic modification enzyme precursor contains an elastase cleavage motif at the N-terminus, the enzyme is probably activated by elastase to activate the elastase afterwards Pseudomonas aeruginosa

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.B16
-
 Pseudomonas aeruginosa

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.24.B16 additional information
-
-
 Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B16 additional information enzyme activates elastase, and the elastolytic activity of thermolysin, human neutrophil elastase, proteinase K, by interacting with the elastin substrate rather than the other enzyme Pseudomonas aeruginosa ?
-
 ?
3.4.24.B16 protein + H2O
-
 Pseudomonas aeruginosa peptides
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.B16 ? x * 22000, SDS-PAGE Pseudomonas aeruginosa

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B16 LasA
-
 Pseudomonas aeruginosa
3.4.24.B16 M23.002 Merops-ID Pseudomonas aeruginosa
3.4.24.B16 staphylolysin
-
 Pseudomonas aeruginosa

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.4.24.B16 Pseudomonas aeruginosa above, isoelectric focussing
-
 9.5