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Literature summary extracted from

  • Tang, B.L.
    ADAMTS: a novel family of extracellular matrix proteases (2001), Int. J. Biochem. Cell Biol., 33, 33-44.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.B11 cytokine stimulation of gene expression in colon carcinoma cell line Mus musculus
3.4.24.B11 interleukin-1 stimulation of gene expression in colon carcinoma cell line Mus musculus
3.4.24.B11 additional information complex formation with alpha2-macroglobulin Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B12 expression in Drosophila S2 cells Bos taurus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B11 additional information knock out mutant mice exhibit significant growth retardation, impaired female fertility and adipose tissue malformation, as well as kidney structure changes Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B11 extracellular matrix, soluble Homo sapiens
-
-
3.4.24.B11 extracellular the mature processed enzyme form is soluble, the unprocessed enzyme proform is associated with the extracellular matrix via the first TSP-1 repeat that can bind to heparin Mus musculus
-
-
3.4.24.B12 extracellular
-
 Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B11 Zn2+ enzyme contains a Zn2+-binding peptidase consensus sequence HEXXH involved in catalysis Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B11 additional information Homo sapiens enzyme is genetically regulated by progesteron in the ovulation process ?
-
 ?
3.4.24.B11 proteins + H2O Mus musculus
-
 peptides
-
 ?
3.4.24.B11 proteins + H2O Homo sapiens
-
 peptides
-
 ?
3.4.24.B12 aggrecan + H2O Bos taurus cleavage site is Glu373-Ala374, reaction is relevant to cartilage degeneration in inflammatory joint diseases 2 aggrecan fragment
-
 ?
3.4.24.B12 proteins + H2O Bos taurus
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B11 Homo sapiens Q9UHI8
-
-
3.4.24.B11 Mus musculus
-
-
-
3.4.24.B12 Bos taurus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B11 proteolytic modification cleavage of the proform by furin at the furin cleavage site Mus musculus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.B12
-
 Bos taurus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.24.B11 proteolytic degradation of proteins enzyme has multiple and non-redundant functions in organogenesis, enzyme inhibits endothelial cell proliferation Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B11 colonic cancer cell selective expression and secretion Mus musculus
-
3.4.24.B11 heart low expression level Mus musculus
-
3.4.24.B11 kidney low expression level Mus musculus
-
3.4.24.B11 kidney high level gene expression Homo sapiens
-
3.4.24.B11 additional information intravenous administration of lipopolysaccharides resulted in inflammation which induced the enzyme expression exclusively in heart and kidney Mus musculus
-
3.4.24.B12 cartilage nasal Bos taurus
-
3.4.24.B12 placenta gene expression Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B11 additional information enzyme is genetically regulated by progesteron in the ovulation process Homo sapiens ?
-
 ?
3.4.24.B11 proteins + H2O
-
 Mus musculus peptides
-
 ?
3.4.24.B11 proteins + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.B11 proteins + H2O enzyme suppresses FGF2-induced vascularization in a cornea pocket assay and inhibited VEGF-induced angiogenesis in a chorioallantoic membrane assay Homo sapiens peptides
-
 ?
3.4.24.B12 aggrecan + H2O cleavage site is Glu373-Ala374 Bos taurus 2 aggrecan fragment
-
 ?
3.4.24.B12 aggrecan + H2O cleavage site is Glu373-Ala374, reaction is relevant to cartilage degeneration in inflammatory joint diseases Bos taurus 2 aggrecan fragment
-
 ?
3.4.24.B12 proteins + H2O
-
 Bos taurus peptides
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.B11 More enzyme is composed of a ADAM-like protease domain, a disintegrin-like, a thrombospondin type 1 repeat and a cysteine-rich domain, but no transmembrane domain Mus musculus
3.4.24.B11 More enzyme is composed of a ADAM-like protease domain, a disintegrin-like, a thrombospondin type 1 repeat and a cysteine-rich domain, but no transmembrane domain Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B11 a disintegrin and metalloproteinase with thrombospondin motifs 1
-
 Mus musculus
3.4.24.B11 a disintegrin and metalloproteinase with thrombospondin motifs 1
-
 Homo sapiens
3.4.24.B11 ADAMTS1
-
 Mus musculus
3.4.24.B11 ADAMTS1
-
 Homo sapiens
3.4.24.B11 M12.222 Merops-ID Mus musculus
3.4.24.B11 M12.222 Merops-ID Homo sapiens
3.4.24.B11 METH-1
-
 Homo sapiens
3.4.24.B12 a disintegrin and metalloproteinase with thrombospondin motifs 5
-
 Bos taurus
3.4.24.B12 ADAMTS11
-
 Bos taurus
3.4.24.B12 ADAMTS5
-
 Bos taurus
3.4.24.B12 aggrecanase-2
-
 Bos taurus
3.4.24.B12 implantin
-
 Bos taurus
3.4.24.B12 M12.225 Merops-ID Bos taurus