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Literature summary extracted from

  • Ryo, M.
    Some properties of bacterial dipeptidyl peptidase IV (2001), Int. Congr. Ser., 1218, 395-399.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.5 diisopropylfluorophosphate marked inhibition at 1 mM Streptococcus salivarius
3.4.14.5 Gly-Pro competitive inhibition Streptococcus salivarius
3.4.14.5 additional information no inhibition by sulfhydryl-blocking agents and metal chelators, no inhibition by Pro, Pro-Gly, and Pro-Gly-Gly Streptococcus salivarius

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.14.5 additional information not affected by various cations Streptococcus salivarius

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.14.5 47000
-
 2 * 47000, SDS-PAGE Streptococcus salivarius
3.4.14.5 109000
-
 gel filtration Streptococcus salivarius

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.5 Streptococcus salivarius
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.14.5 glycoprotein the desialylated enzyme is attacked by proteases Streptococcus salivarius

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.14.5 114fold Streptococcus salivarius

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.14.5 release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline specific for hydrolysis of peptide bond on the carboxylic side of proline residues which are penultimate from the amino terminus Streptococcus salivarius
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.5 Gly-Pro-4-nitroanilide + H2O
-
 Streptococcus salivarius Gly-Pro + 4-nitroaniline
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.14.5 dimer 2 * 47000, SDS-PAGE Streptococcus salivarius

Synonyms

EC Number Synonyms Comment Organism
3.4.14.5 dipeptidyl peptidase IV
-
 Streptococcus salivarius
3.4.14.5 DPPIV
-
 Streptococcus salivarius

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.14.5 8.7
-
 Gly-NaOH buffer Streptococcus salivarius

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.14.5 5.3
-
 Gly-Pro versus Gly-Pro-4-nitroanilide Streptococcus salivarius

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.4.14.5 Streptococcus salivarius
-
-
 4.2