Literature summary extracted from

Selim, T.E.; Ghoneim, H.R.; Abdel Ghaffar, H.A.; Colman, R.W.; Dela Cadena, R.A.
High molecular mass kininogen inhibits cathepsin G-induced platelet activation by forming a complex with cathepsin G (2001), Hematol. J., 2, 371-377.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.20	high molecular mass kininogen	i.e. HK, human, competitive, inhibits platelet activation by the enzyme completely by complex formation with the enzyme	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.20	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.20	high molecular mass kininogen + H2O	human, 120 kDa	Homo sapiens	peptide fragments	after 1 min reaction: 110, 100, and 75 kDa fragments, after 5 min reaction: 10 to 70 kDa fragments, after 60 min: less than 20 kDa fragments	?
3.4.21.20	N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O	chromogenic substrate	Homo sapiens	N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline	-	?

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
3.4.21.20	37	-	assay at	Homo sapiens

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
3.4.21.20	7.4	-	cleavage of high molecular mass kininogen	Homo sapiens

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Release 2023.1 (January 2023)