Literature summary extracted from
Wu, Y.C.; Stanfield, G.M.; Horvitz, H.R.
NUC-1, a caenorhabditis elegans DNase II homolog, functions in an intermediate step of DNA degradation during apoptosis (2000), Genes Dev., 14, 536-548.
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
3.1.22.1 |
gene nuc-1 |
Caenorhabditis elegans |
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
3.1.22.1 |
additional information |
Mutations in nuc-1 block the conversion of TUNEL-reactive DNA to a subsequent TUNEL-unreactive state. |
Caenorhabditis elegans |
Natural Substrates/ Products (Substrates)
EC Number |
Natural Substrates |
Organism |
Comment (Nat. Sub.) |
Natural Products |
Comment (Nat. Pro.) |
Rev. |
Reac. |
---|
3.1.22.1 |
DNA + H2O |
Caenorhabditis elegans |
using TdT-mediated dUTP-nicked-end labelling, TUNEL, is followed DNA fragmentation that occurs in vivo during programmed cell death, Nuc-1 functions in the elimination of TUNEL-reactive DNA ends to a TUNEL nonreactive state |
3'-phosphooligonucleotide |
- |
? |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.1.22.1 |
Caenorhabditis elegans |
- |
- |
- |
Reaction
EC Number |
Reaction |
Comment |
Organism |
Reaction ID |
---|
3.1.22.1 |
endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products |
The pathway for DNA degradation involves three distinct steps. The second step is mediated by the NUC-1. |
Caenorhabditis elegans |
|
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
3.1.22.1 |
DNA + H2O |
degradation of the DNA of apoptotic cells |
Caenorhabditis elegans |
3'-phosphooligonucleotide |
- |
? |
|
3.1.22.1 |
DNA + H2O |
using TdT-mediated dUTP-nicked-end labelling, TUNEL, is followed DNA fragmentation that occurs in vivo during programmed cell death, Nuc-1 functions in the elimination of TUNEL-reactive DNA ends to a TUNEL nonreactive state |
Caenorhabditis elegans |
3'-phosphooligonucleotide |
- |
? |
|
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
3.1.22.1 |
Nuc-1 |
DNase II homolog |
Caenorhabditis elegans |