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Literature summary extracted from

  • Senzaki, H.; Smith, C.J.; Juang, G.J.; Isoda, T.; Mayer, S.P.; Ohler, A.; Paolocci, N.; Tomaselli, G.F.; Hare, J.M.; Kass, D.A.
    Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure (2001), FASEB J., 15, 1718-1726.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.35 (4-(4-[2-ethyl-phenylamino)-methylene]-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-benzoic acid 0.00001 mM, 50% inhibition Canis lupus familiaris

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.35 guanosine 3',5'-cyclic phosphate + H2O Canis lupus familiaris
-
 guanosine 5'-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.35 Canis lupus familiaris
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.35 heart whole myocardium from failing hearts have 50% lower PDE5A expression and 30% less total and EMD82639-inhibitable cGMP-PDE activity Canis lupus familiaris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.35 guanosine 3',5'-cyclic phosphate + H2O
-
 Canis lupus familiaris guanosine 5'-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.35 PDE5A
-
 Canis lupus familiaris
3.1.4.35 phosphodiesterase 5 (cGMP-specific)
-
 Canis lupus familiaris