Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Mitrochkine, A.A.; Eydoux, E.; Gil, G.; Reglier, M.
    Aminoindanes in oxygen atom transfer reactions, 1: Enzymatic hydroxylation by dopamine beta-hydroxylase (1998), Eur. J. Org. Chem., 1998, 1171-1176.
No PubMed abstract available

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.17.1 3.8
-
 2-aminoindane 37°C, 0.2 M acetate buffe, pI 6, with 30 mM NEM, 1 mM K4Fe(CN)6, 5 mM CuSO4 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.17.1 partially, from adrenal medulla after crude extract PEG 6000 precipitation and DEAE-Sepharose chromatography Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 2-aminoindane + ascorbate + O2 Stereochemistry is in contrast to the stereochemical course of pro-R hydroxylation of the DBH/phenethylamine reaction. Studies with stereospecifically deuterium labelled substrate show that the production of (1S)-aminoindanol ir the result of sterospecific pro-S hydrogen abstraction followed by the oxygen binding with overall retention of configuration Bos taurus trans-(1S,2S)-2-amino-1-indanol + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.17.1 DBH
-
 Bos taurus
1.14.17.1 dopamine beta-hydroxylase
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.17.1 ascorbate
-
 Bos taurus