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Literature summary extracted from

  • Erb, E.M.; Stenflo, J.; Drakenberg, T.
    Interaction of bovine coagulation factor X and its glutamic-acid-containing fragments with phospholipid membranes. A surface plasmon resonance study (2002), Eur. J. Biochem., 269, 3041-3046.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.6 extracellular
-
 Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.6 Ca2+ dependent on, cooperative binding, required of the intact enzyme and also of its Gla-domain and EGF-like domain to interact with negatively charged phospholipids containing 25% phosphatidylserine and 75% phosphatidylcholine, 3 Ca2+ per binding partner Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.6 Bos taurus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.6 proteolytic modification the enzyme is processed from factor X to factor Xa Bos taurus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.6 selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.6 blood
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.6 prothrombin + H2O
-
 Bos taurus thrombin + ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.6 More the intact enzyme contains a Gla-domain and a N-terminal EGF-like domain, amino acid residues 1-86, as well as a C-terminal EGF-like domain, amino acid residues 154-183 Bos taurus

Synonyms

EC Number Synonyms Comment Organism
3.4.21.6 coagulation factor X
-
 Bos taurus
3.4.21.6 factor X
-
 Bos taurus
3.4.21.6 factor Xa
-
 Bos taurus
3.4.21.6 More the enzyme belongs to the peptidase family S1, i.e. trypsin family Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
3.4.21.6 additional information the intact enzyme and also of its Gla-domain and EGF-like domain interact with negatively charged phospholipids containing 25% phosphatidylserine and 75% phosphatidylcholine, kinetics Bos taurus