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Literature summary extracted from

  • Gao, J.
    Catalysis by enzyme conformational change as illustrated by orotidine 5'-monophosphate decarboxylase (2003), Curr. Opin. Struct. Biol., 13, 184-192.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.1.23 X-ray structure of ODCase complexed with 6-azaorotidine 5’-phosphate Methanothermobacter thermautotrophicus

Protein Variants

EC Number Protein Variants Comment Organism
4.1.1.23 D70A active site mutant Methanothermobacter thermautotrophicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.23 Orotidine 5'-phosphate Methanothermobacter thermautotrophicus
-
 UMP + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.23 Methanothermobacter thermautotrophicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.1.23 orotidine 5'-phosphate = UMP + CO2 mechanism, thermodynamic data Methanothermobacter thermautotrophicus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.23 2'-deoxyorotidine 5'-phosphate decreased catalytic rate compared with orotidine 5'-phosphate as substrate Methanothermobacter thermautotrophicus 2'-deoxyuridine 5'-phosphate + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate
-
 Methanothermobacter thermautotrophicus UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate mechanism, enzyme conformation is more distorted in the reactant state than in the transition state, the energy released from conformation relaxation provides the predominant contribution to the rate enhancement, the active site consists of a network of charged residues Lys-42, Asp-70, Lys-72, Asp-75b Methanothermobacter thermautotrophicus UMP + CO2
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1.1.23 additional information
-
 additional information
-
 Methanothermobacter thermautotrophicus