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Literature summary extracted from

  • Caslake, M.J.; Packard, C.J.
    Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease (2003), Curr. Opin. Lipidol., 14, 347-352.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.1.47 diagnostics the enzyme is a positive risk factor for coronary disease and measurements of its amount may contribute to the prediction of coronary heart disease risk, especially in individuals with low LDL cholesterol levels Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.47 gene maps to chromosome 6q12.p21.1 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.47 V279F naturally occurring mutantion, ecspecially in Japanese population, loss of enzyme activity, associated with increased risk of stroke and of coronary artery disease Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.47 extracellular plasma Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.47 additional information secretory isozyme is Ca2+-independent Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.47 14000
-
 x * 14000, secretory isozyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O Homo sapiens i.e. platelet-activation factor 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 additional information Homo sapiens the plasma isozyme is associated with LDL, 80%, and HDL, 15-20%, and VLDL, below 5%, particles, where it seems to be independently regulated and to have distinct roles in artherosclerosis, LDL-associated enzyme has a protective role in artheriosclerosis, regulation of lipoprotein-associated enzyme in vivo, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.47 glycoprotein N-glycosylation is essential Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.47 artery wall
-
 Homo sapiens
-
3.1.1.47 macrophage increased enzyme expression in artheriosclerosis Homo sapiens
-
3.1.1.47 additional information wide tissue distribution Homo sapiens
-
3.1.1.47 plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor Homo sapiens 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 additional information lipoprotein-associated enzyme does not hydrolyse native phospholipids Homo sapiens ?
-
 ?
3.1.1.47 additional information the plasma isozyme is associated with LDL, 80%, and HDL, 15-20%, and VLDL, below 5%, particles, where it seems to be independently regulated and to have distinct roles in artherosclerosis, LDL-associated enzyme has a protective role in artheriosclerosis, regulation of lipoprotein-associated enzyme in vivo, overview Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.47 ? x * 14000, secretory isozyme Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.1.47 lipoprotein-associated phospholipase A2
-
 Homo sapiens
3.1.1.47 Lp-PLA2
-
 Homo sapiens
3.1.1.47 PAF acetylhydrolase
-
 Homo sapiens
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Homo sapiens