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Literature summary extracted from
- A study of the effect on nucleophilic hydrolytic activity of pancreatic elastase, trypsin, chymotrypsin, and leucine aminopeptidase by boronic acids in the presence of arabinogalactan: a subsequent study on the hydrolytic activity of chymotrypsin by boronic acids in the presence of mono-, di-, and trisaccharides (2003), Bioorg. Chem., 31, 464-474.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.1 | (Cbz-alanyl)aminomethyl boronic acid | inhibition decreases in the presence of arabinogalactan | Bos taurus |  |
| 3.4.21.1 | (Cbz-phenylalanyl)aminomethyl boronic acid | inhibition decreases in the presence of arabinogalctan | Bos taurus | |
| 3.4.21.1 | 4-fluorophenylboronic acid | - |
Bos taurus | |
| 3.4.21.1 | phenylboronic acid | - |
Bos taurus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.1 | Bos taurus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.1 | benzoyl-Tyr-p-nitroanilide + H2O | - |
Bos taurus | benzoyl-tyrosine + p-nitroaniline | - |
? | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.1 | 1.08 | - |
(Cbz-alanyl)aminomethyl boronic acid | 37°C, pH 8.0 | Bos taurus | |
| 3.4.21.1 | 1.96 | - |
(Cbz-phenylalanyl)aminomethyl boronic acid | 37°C, pH 8.0 | Bos taurus | |
| 3.4.21.1 | 9.7 | - |
phenylboronic acid | 37°C, pH 8.0 | Bos taurus | |
| 3.4.21.1 | 31.01 | - |
4-fluorophenylboronic acid | 37°C, pH 8.0 | Bos taurus | |
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Release 2023.1 (January 2023)
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