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Literature summary extracted from

  • Ketelhut, D.F.; de Mello, M.H.; Veronese, E.L.; Esmeraldino, L.E.; Murakami, M.T.; Arni, R.K.; Giglio, J.R.; Cintra, A.C.; Sampaio, S.V.
    Isolation, characterization and biological activity of acidic phospholipase A2 isoforms from Bothrops jararacussu snake venom (2003), Biochimie, 85, 983-991.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.1.1.4 hanging drop vapor diffusion method Bothrops jararacussu

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 4-bromophenacyl bromide suppresses anticoagulant activity, indirect haemolytic activity and inhibition of platelet aggregation, does not inhibit the induction of edema Bothrops jararacussu

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.4 additional information Bothrops jararacussu SIIISPIIA, SIIISPIIB and SIIISPIIIA show significant anticoagulant activity but no indirect haemolytic activity. SIIISPIIIB shows no anticoagulant activity but presents indirect haemolytic activity. With the exception of SIIISPIIB, which inhibits platelet aggregation, all the others are capable of inducing edema ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Bothrops jararacussu
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.4 4 isoforms: SIIISPIIA, SIIISPIIB, SIIISPIIIA, SIIISPIIIB Bothrops jararacussu

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 venom
-
 Bothrops jararacussu
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.4 97
-
 isoform SIIISPIIIB Bothrops jararacussu
3.1.1.4 270
-
 isoform SIIISPIIIA Bothrops jararacussu
3.1.1.4 279
-
 isoform SIIISPIIB Bothrops jararacussu
3.1.1.4 290
-
 isoform SIIISPIIA Bothrops jararacussu

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 additional information SIIISPIIA, SIIISPIIB and SIIISPIIIA show significant anticoagulant activity but no indirect haemolytic activity. SIIISPIIIB shows no anticoagulant activity but presents indirect haemolytic activity. With the exception of SIIISPIIB, which inhibits platelet aggregation, all the others are capable of inducing edema Bothrops jararacussu ?
-
 ?

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.1.1.4 Bothrops jararacussu isoelectric focusing, pH gradient 5-8.5
-
 5.3