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Literature summary extracted from

  • Caricasole, A.; Sala, C.; Roncarati, R.; Formenti, E.; Terstappen, G.C.
    Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLCbeta1) (2000), Biochim. Biophys. Acta, 1517, 63-72.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.11 two distinct PLCbeta1 cDNAs, PLCbeta1a and b, generated through alternative splicing at their 3’ end, sequencing, overexpression in CHO and PC12 cells, gene structure, located on chromosome 20 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.11 cell membrane inner side, PLCbeta1 Homo sapiens
-
-
3.1.4.11 cytoplasm PLCbeta1 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Homo sapiens key step in the intracellular transduction of a large number of extracellular signals, including neurotransmitters and hormones modulating diverse developmental and functional aspects of the central nervous system 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol second messengers ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Homo sapiens Q9NQ66 PLCbeta1a; two isoforms of PLCbeta1, a and b
-
3.1.4.11 Homo sapiens Q9NQ66 PLCbeta1b; two isoforms of PLCbeta1, a and b
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.11 amygdala highest expression level of PLCbeta1 in brain, especially in the amygdala, caudate nucleus and hippocampus Homo sapiens
-
3.1.4.11 brain adult, highest expression level of PLCbeta1 in brain, especially in the amygdala, caudate nucleus and hippocampus Homo sapiens
-
3.1.4.11 caudate nucleus highest expression level of PLCbeta1 in brain, especially in the amygdala, caudate nucleus and hippocampus Homo sapiens
-
3.1.4.11 hippocampus highest expression level of PLCbeta1 in brain, especially in the amygdala, caudate nucleus and hippocampus Homo sapiens
-
3.1.4.11 additional information expression patterns of the two PLCbeta1 isoforms in a comprehensive panel of tissues Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O phosphoinositide-specific Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O key step in the intracellular transduction of a large number of extracellular signals, including neurotransmitters and hormones modulating diverse developmental and functional aspects of the central nervous system Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol second messengers ?