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Literature summary extracted from

  • Aitken, S.M.; Kirsch, J.F.
    Kinetics of the yeast cystathionine beta-synthase forward and reverse reactions: continuous assays and the equilibrium constant for the reaction (2003), Biochemistry, 42, 571-578.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.22
-
 Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.22 L-cystathione product inhibition Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.22 0.083
-
 L-cystathionine pH 8.6, 37°C, reverse reaction Saccharomyces cerevisiae
4.2.1.22 0.3
-
 L-homocysteine pH 8.6, 37°C Saccharomyces cerevisiae
4.2.1.22 1.2
-
 L-serine pH 8.6, 37°C Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.22 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.22 95% pure Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.22 L-Serine + homocysteine hydroxylgroup of serine is replaced by the thiol of homocysteine Saccharomyces cerevisiae Cystathionine + H2O
-
 r
4.2.1.22 additional information no substrates: D-, L-allo- and D-allo-cystathionine Saccharomyces cerevisiae ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.22 0.56
-
 L-cystathionine pH 8.6, 37°C Saccharomyces cerevisiae
4.2.1.22 6.08
-
 L-cystathionine pH 8.6, 37°C Saccharomyces cerevisiae
4.2.1.22 21.5
-
 L-homocysteine pH 8.6, 37°C Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.1.22 8.3
-
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.22 pyridoxal 5'-phosphate dependent Saccharomyces cerevisiae