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Literature summary extracted from

  • Johnson, J.L.; Cusack, B.; Davies, M.P.; Fauq, A.; Rosenberry, T.L.
    Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate (2003), Biochemistry, 42, 5438-5452.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.7 acetylthiocholine substrate activiation below 1 mM is only seen in W86F mutant but not in wild-type or D74G mutant Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.7
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.7 D74G shows no substrate activation Homo sapiens
3.1.1.7 W86F shows substrate activation at low concentration and substrate inhibition at high concentrations Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 acetylthiocholine substrate inhibition above 1 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.7 0.047
-
 3-(acetamido)-N,N,N-trimethylanilinum pH 8 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.7 W86F and D74G mutant Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.1.7 acetylcholine + H2O = choline + acetate mechanism Homo sapiens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 3-(acetamido)-N,N,N-trimethylanilinum + H2O ATMA Homo sapiens ?
-
 ?
3.1.1.7 acetylthiocholine + H2O
-
 Homo sapiens thiocholine + acetate
-
 ?