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Literature summary extracted from

  • Moor, N.; Lavrik, O.; Favre, A.; Safro, M.
    Prokaryotic and eukaryotic tetrameric phenylalanyl-tRNA synthetases display conservation of the binding mode of the tRNAPhe CCA end (2003), Biochemistry, 42, 10697-10708.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.20 PheOH-AMP
-
 Homo sapiens
6.1.1.20 tRNAPhe Cp75 tRNAPhe with cytosine phosphate residue at position 75 Homo sapiens
6.1.1.20 tRNAPhe s4-U75 tRNAPhe with 4-thiouridine residue at position 75 Homo sapiens
6.1.1.20 tRNAPhe s4-U76 tRNAPhe with 4-thiouridine residue at position 76 Homo sapiens
6.1.1.20 tRNAPhe s4-U77 tRNAPhe with 4-thiouridine residue at position 77 Homo sapiens
6.1.1.20 tRNAPhe s4-Up77 tRNAPhe with 4-thiouridine phosphate residue at position 77 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.1.1.20 0.0015
-
 L-phenylalanine 25°C Homo sapiens
6.1.1.20 0.1
-
 ATP 25°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.20 ATP + L-phenylalanine + tRNAPhe Homo sapiens
-
 AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.20 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
6.1.1.20 ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe tRNAPhe substrate binding mechanism, base-specific interactions between the 3'-end of the tRNA and the enzymes alpha- and beta-subunit Homo sapiens
a

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.1.1.20 0.19
-
 pure enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.20 ATP + L-phenylalanine + tRNAPhe
-
 Homo sapiens AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 ?

Subunits

EC Number Subunits Comment Organism
6.1.1.20 tetramer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
6.1.1.20 CML33
-
 Homo sapiens
6.1.1.20 FRS
-
 Homo sapiens
6.1.1.20 HSPC173
-
 Homo sapiens
6.1.1.20 L-Phenylalanyl-tRNA synthetase
-
 Homo sapiens
6.1.1.20 Phenylalanine translase
-
 Homo sapiens
6.1.1.20 Phenylalanine--tRNA ligase
-
 Homo sapiens
6.1.1.20 Phenylalanine-tRNA synthetase
-
 Homo sapiens
6.1.1.20 Phenylalanyl transfer ribonucleic acid synthetase
-
 Homo sapiens
6.1.1.20 Phenylalanyl-transfer ribonucleate synthetase
-
 Homo sapiens
6.1.1.20 Phenylalanyl-transfer RNA ligase
-
 Homo sapiens
6.1.1.20 Phenylalanyl-transfer RNA synthetase
-
 Homo sapiens
6.1.1.20 Phenylalanyl-tRNA ligase
-
 Homo sapiens
6.1.1.20 Phenylalanyl-tRNA synthetase
-
 Homo sapiens
6.1.1.20 PheRS
-
 Homo sapiens
6.1.1.20 Synthetase, phenylalanyl-transfer ribonucleate
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.1.1.20 25
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.20 ATP
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.1.1.20 0.0002
-
 PheOH-AMP 25°C Homo sapiens
6.1.1.20 0.00035
-
 tRNAPhe s4-Up77 25°C Homo sapiens
6.1.1.20 0.0004
-
 tRNAPhe s4-U77 25°C Homo sapiens
6.1.1.20 0.00064
-
 tRNAPhe s4-U76 25°C Homo sapiens
6.1.1.20 0.00069
-
 tRNAPhe Cp75 25°C Homo sapiens
6.1.1.20 0.00071
-
 tRNAPhe s4-U75 25°C Homo sapiens