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Literature summary extracted from

  • Banerjee, M.; Majumder, R.; Weinreb, G.; Wang, J.; Lentz, B.R.
    role of procoagulant lipids in human prothrombin activation. 2. Soluble phosphatidylserine upregulates and directs factor Xa to appropriate peptide bonds in prothrombin (2002), Biochemistry, 41, 950-957.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.6 1,2-dicaproylphosphatidylserine soluble, upregulates 60fold, and directs factor Xa to appropriate peptide bonds in prothrombin Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.6 Ca2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.6 prothrombin + H2O Homo sapiens prothrombin activation requires proteolysis of 2 bonds and thus involves 2 possible activation pathways, parallel-sequential activation model thrombin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.6 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.6 selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.6 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.6 prothrombin + H2O hydrolysis of Arg322-Ile323 produces meizothrombin as an intermediate, while hydrolysis of Arg273-Thr274 produces prethrombin 2-fragment 1.2 Homo sapiens thrombin + ?
-
 ?
3.4.21.6 prothrombin + H2O prothrombin activation requires proteolysis of 2 bonds and thus involves 2 possible activation pathways, parallel-sequential activation model Homo sapiens thrombin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.6 factor Xa
-
 Homo sapiens
3.4.21.6 More the enzyme belongs to the peptidase family S1, i.e. trypsin family Homo sapiens