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Literature summary extracted from

  • Jeffery, C.J.; Bahnson, B.J.; Chien, W.; Ringe, D.; Petsko, G.A.
    Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator (2000), Biochemistry, 39, 955-964.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
5.3.1.9 enzyme complexed with the competitive inhibitor D-gluconate 6-phosphate, X-ray crystallography at 2.5 A resolution Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.1.9 D-gluconate 6-phosphate
-
 Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.1.9 cytoplasm
-
 Oryctolagus cuniculus 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.1.9 D-glucose 6-phosphate Oryctolagus cuniculus in the cytoplasm, it catalyzes the second step in glycolysis. Outside the cell, it serves as a nerve growth factor and cytokine D-fructose 6-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.1.9 Oryctolagus cuniculus Q9N1E2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.1.9 D-glucose 6-phosphate the active site residues Lys58 and His388 might be involved in catalytic mechanism Oryctolagus cuniculus D-fructose 6-phosphate
-
 ?
5.3.1.9 D-glucose 6-phosphate in the cytoplasm, it catalyzes the second step in glycolysis. Outside the cell, it serves as a nerve growth factor and cytokine Oryctolagus cuniculus D-fructose 6-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
5.3.1.9 dimer the enzyme is a dimer with two alpha/beta-sandwich domains in each subunit Oryctolagus cuniculus

Synonyms

EC Number Synonyms Comment Organism
5.3.1.9 autocrine motility factor
-
 Oryctolagus cuniculus
5.3.1.9 Neuroleukin
-
 Oryctolagus cuniculus