Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Koike, H.; Tomioka, S.; Sorimachi, H.; Saido, T.C.; Maruyama, K.; Okuyama, A.; Fujisawa-Sehara, A.; Ohno, S.; Suzuki, K.; Ishiura, S.
    Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein (1999), Biochem. J., 343, 371-375.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B9 expression of Sec-tagged wild-type and metalloprotease domain deletion mutant in COS-7 cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B9 metalloprotease inhibitor SI-27
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B9 membrane anchored Mus musculus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B9 Mn2+ metalloprotease Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B9 proteins + H2O Mus musculus
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B9 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.B9 recombinant wild-type and mutant from COS-7 cells Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B9 amyloid precursor protein + H2O alpha-secretase activity Mus musculus 90-100 kDa non-amyloid N-terminal protein fragment
-
 ?
3.4.24.B9 proteins + H2O
-
 Mus musculus peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B9 M12.209 Merops-ID Mus musculus
3.4.24.B9 MDC9
-
 Mus musculus
3.4.24.B9 meltrin-gamma
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.B9 37
-
 assay at Mus musculus