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Literature summary extracted from

  • Sucic, J.F.; Moehring, J.M.; Inocencio, N.M.; Luchini, J.W.; Moehring, T.J.
    Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain (1999), Biochem. J., 339, 639-647.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B25 expression in furin-deficient cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.B25 EGTA inhibits at 0.5-2 mM Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.B25 Ca2+ dependent Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B25 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B25 anthrax toxin protective antigen + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.B25 dipththeria toxin + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.B25 insulin proreceptor + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.B25 low density lipoprotein receptor-elated protein + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.B25 additional information no substrate: Pseudomonas exotoxin A Homo sapiens ?
-
 ?
3.4.21.B25 von Willebrand factor precursor + H2O
-
 Homo sapiens mature von Willebrand factor + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B25 PACE4
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.B25 37
-
-
 Homo sapiens

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.4.21.B25 22 30 markedly decreased enzyme activity Homo sapiens