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Literature summary extracted from

  • Hotoda, N.; Koike, H.; Sasagawa, N.; Ishiura, S.
    A secreted form of human ADAM9 has an alpha-secretase activity for APP (2002), Biochem. Biophys. Res. Commun., 293, 800-805.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B9 DNA sequence determination and analysis, expression of the short enzyme form, lacking the transmembrane and the cytoplasmic domains due to a deletion in the EGF-like domain, in COS cells, coexpression of amyloid precursor protein Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B9 extracellular
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B9 additional information metalloproteases Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B9 proteins + H2O Homo sapiens enzymes of the ADAM family play importants roles in cell-cell fusion, intracellular signaling, and other cellular functions peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B9 Homo sapiens Q13443 native short form of ADAM9 lacking the transmembrane and the cytoplasmic domains due to a deletion in the EGF-like domain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B9 brain expression of full length and short enzyme form Homo sapiens
-
3.4.24.B9 heart expression of full length and short enzyme form Homo sapiens
-
3.4.24.B9 liver expression of full length and short enzyme form, with higher level of the short form than in other tissues Homo sapiens
-
3.4.24.B9 lung expression of full length and short enzyme form Homo sapiens
-
3.4.24.B9 trachea expression of full length and short enzyme form Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B9 amyloid precursor protein + H2O enzyme shows alpha-secretase activity Homo sapiens ?
-
 ?
3.4.24.B9 proteins + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.B9 proteins + H2O enzymes of the ADAM family play importants roles in cell-cell fusion, intracellular signaling, and other cellular functions Homo sapiens peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B9 ADAM9
-
 Homo sapiens
3.4.24.B9 M12.209 Merops-ID Homo sapiens
3.4.24.B9 MDC9
-
 Homo sapiens
3.4.24.B9 meltrin-gamma
-
 Homo sapiens