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Literature summary extracted from

  • Huber, W.W.; Scharf, G.; Rossmanith, W.; Prustomersky, S.; Grasl-Kraupp, B.; Peter, B.; Turesky, R.J.; Schulte-Hermann, R.
    The coffee components kahweol and cafestol induce g-glutamylcysteine synthetase, the rate limiting enzyme of chemoprotective glutathione synthesis, in several organs of the rat (2002), Arch. Toxicol., 75, 685-694.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.2.2 cafestol coffee component, induction of the enzyme in vivo, especially in the liver up to 2.4fold, increase in expression of both enzyme subunits Rattus norvegicus
6.3.2.2 kahweol coffee component, induction of the enzyme in vivo, especially in the liver up to 2.4fold, increase in expression of both enzyme subunits Rattus norvegicus

Application

EC Number Application Comment Organism
6.3.2.2 medicine the enzyme may be a key factor in the chemopreventive potential of coffee components kahweol and cafestol Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.2 ATP + L-Glu + L-Cys Rattus norvegicus rate-limiting step of the chemoprotective glutathione synthesis ADP + phosphate + gamma-L-Glu-L-Cys
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.2 Rattus norvegicus
-
 male F344 rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.2 colon
-
 Rattus norvegicus
-
6.3.2.2 kidney
-
 Rattus norvegicus
-
6.3.2.2 liver
-
 Rattus norvegicus
-
6.3.2.2 lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.2 ATP + L-Glu + L-Cys
-
 Rattus norvegicus ADP + phosphate + gamma-L-Glu-L-Cys
-
 ?
6.3.2.2 ATP + L-Glu + L-Cys rate-limiting step of the chemoprotective glutathione synthesis Rattus norvegicus ADP + phosphate + gamma-L-Glu-L-Cys
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.2.2 dimer heavy and light subunit Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
6.3.2.2 gamma-Glutamylcysteine synthetase
-
 Rattus norvegicus
6.3.2.2 GCS
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.2 ATP
-
 Rattus norvegicus