Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kim, J.H.; Kim, S.I.; Song, K.S.
    Prolyl endopeptidase inhibitors from green tea (2001), Arch. Pharm. Res., 24, 292-296.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.26 medicine the inhibitors (-)-epigallocatechin gallate, (-)-epicatechin gallate and (+)-gallocatechin are expected to be useful for preventing and curing of Alzheimer‘s disease Elizabethkingia meningoseptica

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.26 (+)-gallocatechin IC50: 0.000109 mM, expected to be useful for preventing and curing of Alzheimer‘s disease Elizabethkingia meningoseptica
3.4.21.26 (-)-epicatechin gallate IC50: 10.2 mM, expected to be useful for preventing and curing of Alzheimer‘s disease Elizabethkingia meningoseptica
3.4.21.26 (-)-epigallocatechin gallate IC50: 0.000142 mM, expected to be useful for preventing and curing of Alzheimer‘s disease Elizabethkingia meningoseptica

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.26 Elizabethkingia meningoseptica
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.26 benzyloxycarbonyl-Gly-Pro-p-nitroanilide + H2O
-
 Elizabethkingia meningoseptica benzyloxycarbonyl-Gly-Pro + p-nitroaniline
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.21.26 0.000109
-
 IC50: 0.000109 mM, expected to be useful for preventing and curing of Alzheimer‘s disease Elizabethkingia meningoseptica (+)-gallocatechin
3.4.21.26 0.000142
-
 IC50: 0.000142 mM, expected to be useful for preventing and curing of Alzheimer‘s disease Elizabethkingia meningoseptica (-)-epigallocatechin gallate
3.4.21.26 10.2
-
 IC50: 10.2 mM, expected to be useful for preventing and curing of Alzheimer‘s disease Elizabethkingia meningoseptica (-)-epicatechin gallate