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Literature summary extracted from

  • Tuinstra, R.L.; Burgner, J.W.2nd.; Miziorko, H.M.
    Investigation of the oligomeric status of the peroxisomal isoform of human 3-hydroxy-3-methylglutaryl-CoA lyase (2002), Arch. Biochem. Biophys., 408, 286-294.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.3.4 dithiothreitol 8fold stimulation at 5 mM Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
4.1.3.4 C323S shows less dithiothreitol activation than wild-type enzyme Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.3.4 peroxisome
-
 Homo sapiens 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.3.4 additional information Homo sapiens last step in ketogenesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.3.4
-
 Homo sapiens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.3.4 107
-
 C323S mutant Homo sapiens
4.1.3.4 114
-
 wild-type Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.4 (S)-3-Hydroxy-3-methylglutaryl-CoA
-
 Homo sapiens Acetyl-CoA + acetoacetate
-
 ?
4.1.3.4 additional information last step in ketogenesis Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.3.4 dimer crosslinking experiments with dibromopopanone Homo sapiens
4.1.3.4 tetramer analytical ultracentrifugation, enzyme exists as a mixture of dimers and tetramers Homo sapiens