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Literature summary extracted from

  • Serfass, L.; Carr, H.S.; Aschenbrenner, L.M.; Burstyn, J.N.
    Calcium ion downregulates soluble guanylyl cyclase activity: Evidence for a two-metal ion catalytic mechanism (2001), Arch. Biochem. Biophys., 387, 47-56.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.2 NO
-
 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.2 Ca2+ inhibition of both, the basal and NO-stimulated forms of sGC, competitive vs. Mg2+, noncompetitive vs. MgGTP Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.2 soluble
-
 Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.2 Mg2+ one Mg2+ is primarily associated with the enzyme and the second is directly bound to the alpha, beta and gamma phosphates of GTP Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.2 GTP Bos taurus
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.2
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 lung
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
-
 Bos taurus 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 sGC
-
 Bos taurus
4.6.1.2 soluble guanylyl cyclase
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.6.1.2 0.029
-
 Ca2+ 37°C, pH 7.4, competitive vs. Mg2+ Bos taurus
4.6.1.2 0.096
-
 Ca2+ 37°C, pH 7.4, noncompetitive vs. MgGTP Bos taurus