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Literature summary extracted from

  • Iruela-Arispe, M.L.; Carpizo, D.; Luque, A.
    ADAMTS1: a matrix metalloprotease with angioinhibitory properties (2003), Ann. N. Y. Acad. Sci., 995, 183-190.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B11 expression of His-Myc-tagged wild-type enzyme and tagged mutant E385A, as well as truncated construct comprising the amino acid residues 549-951, in the carcinoma cell line T47D Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B11 E385A point mutation in the zinc binding domain, catalytically inactive mutant Homo sapiens
3.4.24.B11 additional information induction of tumor growth in nude mice by injection of carcinoma cells, cell line T47D expressing the recombinant His-Myc-tagged wild-type or mutant E385A enzyme, number and distribution of vessels in the tumors are reduced compared to control tumors, high degree of edema and necrosis, the truncated construct comprising the amino acid residues 549-951 had no effect on tumor growth, but the isolated first TSP1 repeat does Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B11 extracellular secretion Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B11 additional information Homo sapiens interaction with heparin via the first TSP1 domain at the C-terminal part, enzyme shows an antiangiogenic effect, the enzyme is able to shed proteins from the surface of the endothelium ?
-
 ?
3.4.24.B11 proteins + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B11 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.24.B11 proteolytic degradation of proteins C-terminal catalytic domain Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B11 T47-D cell low expression level Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B11 additional information vascular endothelial growth factor 165 and vascular endothelial growth factor 165 receptor tyrosine kinase are no substrates for proteolytic cleavage, but the enzyme blocks endothelial vascularization by inhibiting the necessary phosphorylation of the receptor Homo sapiens ?
-
 ?
3.4.24.B11 additional information interaction with heparin via the first TSP1 domain at the C-terminal part, enzyme shows an antiangiogenic effect, the enzyme is able to shed proteins from the surface of the endothelium Homo sapiens ?
-
 ?
3.4.24.B11 proteins + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.B11 proteins + H2O rather restricted substrate specificity Homo sapiens peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B11 ADAMTS1
-
 Homo sapiens
3.4.24.B11 M12.222 Merops-ID Homo sapiens
3.4.24.B11 METH1
-
 Homo sapiens