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Literature summary extracted from

  • Young, M.E.; Goodwin, G.W.; Ying, J.; Guthrie, P.; Wilson, C.R.; Laws, F.A.; Taegtmeyer, H.
    Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids (2001), Am. J. Physiol. Endocrinol. Metab., 280, E471-479.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.9 fatty acid increases MCD expression in heart and skeletal muscle Rattus norvegicus
4.1.1.9 additional information high-fat feeding, fasting and streptozotocin-induced diabetes increase the plasma concentration of nonesterified fatty acids, with a concomitant increase in both heart and skeletal muscle MCD mRNA Rattus norvegicus
4.1.1.9 WY-14643 specifically stimulates the peroxisome proliferator-activated receptor-alpha increasing MCD expression and activity in heart and skeletal muscle Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.9 additional information troglitazone, a specific peroxisome proliferator-activated receptor-gamma agonist, decreases MCD expression, no effect on MCD activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.9 Malonyl-CoA Rattus norvegicus degradation of malonyl-CoA, MCD is regulated both transcriptionally and posttranscriptionally, fatty acids induce MCD gene expression Acetyl-CoA + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.9 Rattus norvegicus
-
 male Sprague-Dawley rats, dietary manipulated
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.9 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.9 Malonyl-CoA
-
 Rattus norvegicus Acetyl-CoA + CO2
-
 ?
4.1.1.9 Malonyl-CoA degradation of malonyl-CoA, MCD is regulated both transcriptionally and posttranscriptionally, fatty acids induce MCD gene expression Rattus norvegicus Acetyl-CoA + CO2
-
 ?