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Literature summary extracted from

  • Parag, H.A.; Dimitrovsky, D.; Raboy, B.; Kulka, R.G.
    Selective ubiquitination of calmodulin by UBC4 and a putative ubiquitin protein ligase (E3) from Saccharomyces cerevisiae (1993), FEBS Lett., 325, 242-246.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.2.B11 additional information calmodulin is not ubiquitinated by the enzyme unless E1 and UBC4 are present Saccharomyces cerevisiae
2.3.2.B11 additional information weak, but distinct activity is observed when UBC4 is replaced by UBC1 Saccharomyces cerevisiae
2.3.2.B11 additional information traces of activity are also observed when RAD6 replaces UBC4 Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.B11 EGTA
-
 Saccharomyces cerevisiae
2.3.2.B11 Trifluoperazine 0.03 mM Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.2.B11 Ca2+ required Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.B11 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.B11 additional information no activity with beta-lactoglobulin, beta-casein, kappa-casein, alpha-casein and oxidized ribonuclease Saccharomyces cerevisiae ?
-
 ?
2.3.2.B11 [RING-E3-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [calmodulin]-L-lysine specific for calmodulin Saccharomyces cerevisiae [RING-E3-ubiquitin-carrier protein]-L-cysteine + [calmodulin]-N6-ubiquitinyl-L-lysine
-
 ?