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Literature summary extracted from

  • Braus, G.H.; Luger, K.; Paravicini, G.; Schmidheini, T.; Kirschner, K.; Huetter, R.
    The role of the TRP1 gene in tryptophan biosynthesis (1988), J. Biol. Chem., 263, 7868-7875.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.1.24 separate enzyme encoded by an independent gene, not associated with indole-3-glycerol-phosphate synthetase Saccharomyces cerevisiae
5.3.1.24 TRP1 gene regulation, cloning Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.3.1.24 0.004 0.005 N-(5-phospho-beta-D-ribosyl)anthranilate 30°C Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.1.24 23000
-
 gel filtration Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.1.24 N-(5-phospho-beta-D-ribosyl)anthranilate Saccharomyces cerevisiae third step in tryptophan biosynthesis 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
5.3.1.24 N-(5-phospho-beta-D-ribosyl)anthranilate Saccharomyces cerevisiae involved in tryptophan biosynthesis from chorismate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.1.24 Saccharomyces cerevisiae
-
 separate enzyme encoded by an independent gene, not associated with indole-3-glycerol-phosphate synthetase
-
5.3.1.24 Saccharomyces cerevisiae
-
 transformant strain RH218 (YARp1)
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.1.24 165fold Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.3.1.24 additional information
-
-
 Saccharomyces cerevisiae
5.3.1.24 102
-
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.1.24 N-(5-phospho-beta-D-ribosyl)anthranilate
-
 Saccharomyces cerevisiae 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ir
5.3.1.24 N-(5-phospho-beta-D-ribosyl)anthranilate third step in tryptophan biosynthesis Saccharomyces cerevisiae 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
5.3.1.24 N-(5-phospho-beta-D-ribosyl)anthranilate involved in tryptophan biosynthesis from chorismate Saccharomyces cerevisiae 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
5.3.1.24 monomer
-
 Saccharomyces cerevisiae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.3.1.24 50 60 N-(5-phospho-beta-D-ribosyl)anthranilate 30°C Saccharomyces cerevisiae