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Literature summary extracted from
- Tryptophan biosynthetic genes in eukaryotic microorganisms (1986), Annu. Rev. Microbiol., 40, 55-77.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.3.1.24 | overview over trp/TRP genes encoding PRAI, functional organization of enzymes of tryptophan biosynthesis | Escherichia coli |
| 5.3.1.24 | overview over trp/TRP genes encoding PRAI, functional organization of enzymes of tryptophan biosynthesis | Saccharomyces cerevisiae |
| 5.3.1.24 | overview over trp/TRP genes encoding PRAI, functional organization of enzymes of tryptophan biosynthesis | Aspergillus nidulans |
| 5.3.1.24 | overview over trp/TRP genes encoding PRAI, functional organization of enzymes of tryptophan biosynthesis | Neurospora crassa |
| 5.3.1.24 | overview over trp/TRP genes encoding PRAI, functional organization of enzymes of tryptophan biosynthesis | Schizosaccharomyces pombe |
| 5.3.1.24 | overview over trp/TRP genes encoding PRAI, functional organization of enzymes of tryptophan biosynthesis | Coprinopsis lagopus |
| 5.3.1.24 | separate enzyme encoded by an independent gene, not associated with indole-3-glycerol-phosphate synthetase | Saccharomyces cerevisiae |
| 5.3.1.24 | TRP1 gene encoding multifunctional enzyme is cloned in Escherichia coli and sequenced | Neurospora crassa |
| 5.3.1.24 | TRP1 gene is cloned in Escherichia coli and sequenced | Saccharomyces cerevisiae |
| 5.3.1.24 | TRPC gene encoding multifunctional enzyme is cloned in Escherichia coli and sequenced | Aspergillus nidulans |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | Escherichia coli | third step in tryptophan biosynthesis | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? |  |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | Saccharomyces cerevisiae | third step in tryptophan biosynthesis | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | Aspergillus nidulans | third step in tryptophan biosynthesis | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | Neurospora crassa | third step in tryptophan biosynthesis | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | Schizosaccharomyces pombe | third step in tryptophan biosynthesis | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | Coprinopsis lagopus | third step in tryptophan biosynthesis | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | Coprinopsis radiata | third step in tryptophan biosynthesis | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | Escherichia coli | involved in tryptophan biosynthesis from chorismate | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | Saccharomyces cerevisiae | involved in tryptophan biosynthesis from chorismate | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | Aspergillus nidulans | involved in tryptophan biosynthesis from chorismate | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | Neurospora crassa | involved in tryptophan biosynthesis from chorismate | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | Schizosaccharomyces pombe | involved in tryptophan biosynthesis from chorismate | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | Coprinopsis lagopus | involved in tryptophan biosynthesis from chorismate | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | Coprinopsis radiata | involved in tryptophan biosynthesis from chorismate | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.1.24 | Aspergillus nidulans | - |
multifunctional indole-3-glycerol-phosphate synthetase/PRA isomerase complex | - |
| 5.3.1.24 | Coprinopsis lagopus | - |
- |
- |
| 5.3.1.24 | Coprinopsis radiata | - |
multifunctional indole-3-glycerol-phosphate synthetase/PRA isomerase complex | - |
| 5.3.1.24 | Escherichia coli | - |
- |
- |
| 5.3.1.24 | Neurospora crassa | - |
multifunctional indole-3-glycerol-phosphate synthetase/PRA isomerase complex | - |
| 5.3.1.24 | Saccharomyces cerevisiae | - |
separate enzyme encoded by an independent gene, not associated with indole-3-glycerol-phosphate synthetase | - |
| 5.3.1.24 | Schizosaccharomyces pombe | - |
multifunctional indole-3-glycerol-phosphate synthetase/PRA isomerase complex | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | - |
Escherichia coli | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | - |
Saccharomyces cerevisiae | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | - |
Aspergillus nidulans | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | - |
Neurospora crassa | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | - |
Schizosaccharomyces pombe | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | - |
Coprinopsis lagopus | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | - |
Coprinopsis radiata | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | third step in tryptophan biosynthesis | Escherichia coli | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | third step in tryptophan biosynthesis | Saccharomyces cerevisiae | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | third step in tryptophan biosynthesis | Aspergillus nidulans | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | third step in tryptophan biosynthesis | Neurospora crassa | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | third step in tryptophan biosynthesis | Schizosaccharomyces pombe | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | third step in tryptophan biosynthesis | Coprinopsis lagopus | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | third step in tryptophan biosynthesis | Coprinopsis radiata | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | involved in tryptophan biosynthesis from chorismate | Escherichia coli | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | involved in tryptophan biosynthesis from chorismate | Saccharomyces cerevisiae | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | involved in tryptophan biosynthesis from chorismate | Aspergillus nidulans | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | involved in tryptophan biosynthesis from chorismate | Neurospora crassa | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | involved in tryptophan biosynthesis from chorismate | Schizosaccharomyces pombe | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | involved in tryptophan biosynthesis from chorismate | Coprinopsis lagopus | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| 5.3.1.24 | N-(5-phospho-beta-D-ribosyl)anthranilate | involved in tryptophan biosynthesis from chorismate | Coprinopsis radiata | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.3.1.24 | dimer | active form | Neurospora crassa |
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