BRENDA - Enzyme Database

Interaction of inhibitors with phosphoenolpyruvate mutase: implications for the reaction mechanism and the nature of the active site

Seidel, H.M.; Knowles, J.R.; Biochemistry 33, 5641-5646 (1994)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.4.2.9
Br-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
Cl-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
H2PO2-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
HCO2-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
HCO3-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
HPO32-
competitive
Tetrahymena pyriformis
5.4.2.9
I-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
isocitrate analogues
-
Tetrahymena pyriformis
5.4.2.9
NO2-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
NO3-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
oxalate
synergistic inhibition in combination with a small noncompetitive inhibitor
Tetrahymena pyriformis
5.4.2.9
PO43-
competitive
Tetrahymena pyriformis
5.4.2.9
SO32-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
SO42-
competitive
Tetrahymena pyriformis
5.4.2.9
VO43-
competitive
Tetrahymena pyriformis
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
5.4.2.9
0.01
-
Phosphonopyruvate
pH 7.5
Tetrahymena pyriformis
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.4.2.9
Streptomyces hygroscopicus
-
-
-
5.4.2.9
Tetrahymena pyriformis
-
-
-
Reaction
EC Number
Reaction
Commentary
Organism
5.4.2.9
phosphoenolpyruvate = 3-phosphonopyruvate
mechanism
Streptomyces hygroscopicus
5.4.2.9
phosphoenolpyruvate = 3-phosphonopyruvate
mechanism
Tetrahymena pyriformis
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.4.2.9
phosphoenolpyruvate
-
648835
Tetrahymena pyriformis
3-phosphonopyruvate
-
648835
Tetrahymena pyriformis
?
5.4.2.9
phosphoenolpyruvate
-
648835
Streptomyces hygroscopicus
3-phosphonopyruvate
-
648835
Streptomyces hygroscopicus
?
Turnover Number [1/s]
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
5.4.2.9
150
-
Phosphonopyruvate
pH 7.5
Tetrahymena pyriformis
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
5.4.2.9
0.025
-
oxalate
pH 7.5
Tetrahymena pyriformis
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.4.2.9
Br-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
Cl-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
H2PO2-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
HCO2-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
HCO3-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
HPO32-
competitive
Tetrahymena pyriformis
5.4.2.9
I-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
isocitrate analogues
-
Tetrahymena pyriformis
5.4.2.9
NO2-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
NO3-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
oxalate
synergistic inhibition in combination with a small noncompetitive inhibitor
Tetrahymena pyriformis
5.4.2.9
PO43-
competitive
Tetrahymena pyriformis
5.4.2.9
SO32-
noncompetitive
Tetrahymena pyriformis
5.4.2.9
SO42-
competitive
Tetrahymena pyriformis
5.4.2.9
VO43-
competitive
Tetrahymena pyriformis
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
5.4.2.9
0.025
-
oxalate
pH 7.5
Tetrahymena pyriformis
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
5.4.2.9
0.01
-
Phosphonopyruvate
pH 7.5
Tetrahymena pyriformis
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.4.2.9
phosphoenolpyruvate
-
648835
Tetrahymena pyriformis
3-phosphonopyruvate
-
648835
Tetrahymena pyriformis
?
5.4.2.9
phosphoenolpyruvate
-
648835
Streptomyces hygroscopicus
3-phosphonopyruvate
-
648835
Streptomyces hygroscopicus
?
Turnover Number [1/s] (protein specific)
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
5.4.2.9
150
-
Phosphonopyruvate
pH 7.5
Tetrahymena pyriformis